α2,6-Sialoglycan-regulated antitumor immunity of tumor-infiltrating CD8

Shuyu Liang, Qi Tang, Yilan Guo, Shaoran Zhang, Qitao Song, Peng Dai, Xing Chen

Abstract read

In one paragraph

Article in Nature chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shuyu Liang *College of Chemistry and Molecular Engineering, Peking University, Beijing, China.

Qi Tang *College of Chemistry and Molecular Engineering, Peking University, Beijing, China. tangqi@pku.edu.cn.ORCID http://orcid.org/0000-0002-1658-4712

Yilan GuoCollege of Chemistry and Molecular Engineering, Peking University, Beijing, China.

Shaoran ZhangCollege of Chemistry and Molecular Engineering, Peking University, Beijing, China.ORCID http://orcid.org/0000-0002-3124-9656

Qitao SongCollege of Chemistry and Molecular Engineering, Peking University, Beijing, China.

Peng DaiCollege of Chemistry and Molecular Engineering, Peking University, Beijing, China.ORCID http://orcid.org/0000-0002-4581-3473

Xing ChenCollege of Chemistry and Molecular Engineering, Peking University, Beijing, China. xingchen@pku.edu.cn.ORCID http://orcid.org/0000-0002-3058-7370

Funding

China Postdoctoral Science Foundation 2025M780883National Natural Science Foundation of China (National Science Foundation of China) 22250010, 22321005, 9248001, 22407006, 22377002

6 · The paper itself

Abstract

Cell-surface sialoglycans overexpressed on cancer cells suppress activation of tumor-infiltrating immune cells (TIICs) and thus represent promising targets for cancer immunotherapy. However, the functional roles of sialylation in TIICs remain incompletely understood. Here we developed a strategy for single-cell correlative analysis of α2,3- and α2,6-linked sialoglycans and transcriptomes to determine the correlations of cell-surface sialylation with gene expression of the same cells in a linkage-specific manner by single-cell RNA sequencing. We found that α2,3- and α2,6-sialoglycans were distinctively regulated across specific TIIC subpopulations in murine tumors. Notably, downregulation of α2,6-sialoglycans was identified as a cell-surface marker for intratumoral tumor-specific antigen-reactive CD8

Identifiers

PMID42680874

DOI10.1126/science.aad0501

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.