Evidence map›Paper›PMID 42680802›Full record

ArticleExperimental & molecular medicine2026

JMJD3-mediated HADH demethylation orchestrates hepatocyte maturation through fatty acid β-oxidation-dependent histone acetylation.

Haibin Wu, Sen Chen, Huanhuan Shan, Wenjiao Yan, Changlu Qin, Shoupei Liu, Xiangting Cao, Jinzhi Du, Yongjian Zhou, Yuyou Duan

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In one paragraph

Article in Experimental & molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Haibin WuDepartment of Gastroenterology and Hepatology, Guangzhou Digestive Disease Center, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, China.
Sen ChenDepartment of Gastroenterology and Hepatology, Guangzhou Digestive Disease Center, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, China.
Huanhuan ShanDepartment of Gastroenterology and Hepatology, Guangzhou Digestive Disease Center, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, China.
Wenjiao YanDepartment of Gastroenterology and Hepatology, Guangzhou Digestive Disease Center, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, China.
Changlu QinDepartment of Gastroenterology and Hepatology, Guangzhou Digestive Disease Center, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, China.
Shoupei LiuDepartment of Gastroenterology and Hepatology, Guangzhou Digestive Disease Center, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, China.
Xiangting CaoDepartment of Gastroenterology and Hepatology, Guangzhou Digestive Disease Center, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, China.
Jinzhi DuSchool of Medicine, South China University of Technology, Guangzhou, China.
Yongjian ZhouDepartment of Gastroenterology and Hepatology, Guangzhou Digestive Disease Center, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, China.
Yuyou DuanDepartment of Gastroenterology and Hepatology, Guangzhou Digestive Disease Center, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, China. yuyouduan@scut.edu.cn.ORCID http://orcid.org/0000-0002-1402-7402

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Functionally mature hepatocyte generation requires coordinated genetic, metabolic, and epigenetic regulation. Although transcriptional regulation governing hepatocyte differentiation has been extensively studied, how metabolic remodeling interacts with epigenetic regulation during hepatocyte maturation remains poorly understood. Using a human embryonic stem cell-derived hepatocyte organoid differentiation model, we identified JMJD3 as a critical regulator of hepatocyte maturation through metabolic-epigenetic coupling. Mechanistically, JMJD3 activated the fatty acid β-oxidation (FAO) enzyme HADH by removing repressive H3K27me3 marks at its locus, thereby promoting FAO activity during hepatocyte maturation. Enhanced FAO increased acetyl-CoA production, which subsequently promoted EP300-mediated H3K27ac deposition at hepatocyte maturation-associated genes. Functional inhibition of JMJD3, HADH, or FAO impaired hepatocyte maturation, resulting in lipid droplet accumulation and reduced expression of hepatocyte maturation markers. Conversely, restoration of acetyl-CoA partially rescued these maturation defects, supporting a functional link between FAO-dependent metabolism and histone acetylation. Collectively, our findings establish a JMJD3-HADH-FAO-acetyl-CoA regulatory axis that coordinates metabolic remodeling and epigenetic regulation during hepatocyte maturation.

Indexed as

Fatty AcidsHepatocytesHistonesJumonji Domain-Containing Histone DemethylasesAcetylationAcetyl Coenzyme ACell DifferentiationDemethylationEpigenesis, GeneticHumansOxidation-ReductionAcetyl Coenzyme AFatty AcidsHistonesJumonji Domain-Containing Histone DemethylasesKDM6B protein, human

Identifiers

PMID42680802
PMCPMC13633256

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.