Evidence map›Paper›PMID 42680799›Full record

ArticleActa pharmacologica Sinica2026

YAP-mediated mechanotransduction promotes hepatocellular carcinoma progression by targeting ATP1A1/CXCL1 axis.

Meng-Nan Zhang, Xin-Peng Wen, Jing-Yi Liu, Ying Xiong, Makoto Miyagishi, Vivi Kasim, Shou-Rong Wu

Abstract read
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In one paragraph

Article in Acta pharmacologica Sinica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Meng-Nan Zhang *Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, 400044, China.
Xin-Peng Wen *Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, 400044, China.
Jing-Yi Liu *Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, 400044, China.
Ying XiongKey Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, 400044, China.
Makoto MiyagishiLife Science Innovation, School of Integrative and Global Majors, University of Tsukuba, Tsukuba, 305-0006, Japan.
Vivi KasimKey Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, 400044, China. vivikasim@cqu.edu.cn.
Shou-Rong WuKey Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, 400044, China. shourongwu@cqu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular matrix (ECM) stiffness is a critical biomechanical factor that plays a key role in tumor progression, influencing tumor behavior and driving its malignancy. Transcriptional co-activator yes-associated transcriptional regulator (YAP) is a well-established mechanosensitive regulator; however, the molecular mechanisms by which matrix stiffness-mediated YAP activation promotes tumor progression through transcriptional regulation remain incompletely defined. Here, using cross-omics analysis, in vitro, and in vivo experiments, we identified ATPase Na

Indexed as

hepatocellular carcinomamatrix stiffnesstumorigenesistumor microenvironmentYAP

Identifiers

PMID42680799

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.