ArticleCommunications medicine2026
Eating jetlag based on meal timing discrepancies and risk of cardiovascular disease using the prospective cohort NutriNet-Santé.
Article in Communications medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03335644 (The NutriNet-Santé Study. A Web-based Prospective Cohort Study of the Relationship Between Nutrition and Health and of Dietary Patterns and Nutritional Status Predictors), which is not on this map. Not yet cited in PubMed.
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The trial behind it
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The NutriNet-Santé Study. A Web-based Prospective Cohort Study of the Relationship Between Nutrition and Health and of Dietary Patterns and Nutritional Status Predictors
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Authors and funding
19 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEating jetlag is an emerging concept defined as meal timing regularity between free and work days. We evaluated the association between eating jetlag and the risk of cardiovascular disease in a French cohort.
methodsData of 104,806 participants (79% women, mean age=42.7 years (SD 14.6)) were collected from the NutriNet-Santé prospective cohort (2009-2023). Cardiovascular disease was self-reported and validated against medical records. Eating jetlag intensity was calculated using times of first and last caloric intakes in repeated 24-hour dietary records (5.8 (SD 3.2) records on average)), as the absolute difference between weekends and weekdays, and its associations with cardiovascular disease risk were assessed through multi-adjusted Cox models. Eating jetlag direction was assessed using 3 categories: "Advance", "Maintenance", "Delay", in weekends compared to weekdays.
resultsDuring a median follow-up of 8.1 years, eating jetlag was associated, in male participants, with higher cardiovascular disease (HR = 1.14 [1.05-1.23]) and coronary heart disease (HR = 1.21 [1.11-1.33]) risks. In males, participants in the "Advance" group had higher risks of cardiovascular and coronary heart diseases (HR = 1.44 [1.08-1.93], and HR = 1.68 [1.19-2.39], respectively) compared to those in the "Maintenance" group; while those in the "Delay" group had a higher coronary heart disease risk (HR = 1.36 [1.05-1.77]).
conclusionOur results suggest a role for meal timing regularity between weekends and weekdays in CVD etiology, independently of sleep duration and diet quality, specifically in males. If confirmed in other studies, meal timing regularity could be a strategy to mitigate cardiovascular disease risk.
trial registrationNCT03335644.
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