Evidence map›Paper›PMID 42680774›Full record

ArticleNature communications2026

YTHDC1 functions as a molecular chaperone to suppress ALS-linked hnRNPA1 mutants from aggregation.

Kang Ren, Mingjie Cheng, Qiudan Luo, Boxin Zhang, Haosheng Zhang, Zhe Li, Yuxin Liu, Yujie Wang, Ting Kang, Xiaoming Dai and 3 more

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kang Ren *Institute of Modern Biology, Department of Neurosurgery, Affiliated Nanjing Drum Tower Hospital, Nanjing University, Nanjing, Jiangsu, China.ORCID 0009-0000-0870-8327
Mingjie Cheng *Institute of Modern Biology, Department of Hematology, Affiliated Nanjing Drum Tower Hospital, Nanjing University, Nanjing, Jiangsu, China.
Qiudan LuoInstitute of Modern Biology, Department of Neurosurgery, Affiliated Nanjing Drum Tower Hospital, Nanjing University, Nanjing, Jiangsu, China.
Boxin ZhangMOE Key Laboratory of Model Animals for Disease Study, Jiangsu Key Laboratory of Molecular Medicine, Model Animal Research Center, Medical School of Nanjing University, Nanjing, Jiangsu, China.
Haosheng ZhangInstitute of Modern Biology, Department of Hematology, Affiliated Nanjing Drum Tower Hospital, Nanjing University, Nanjing, Jiangsu, China.
Zhe LiInstitute of Modern Biology, Department of Neurosurgery, Affiliated Nanjing Drum Tower Hospital, Nanjing University, Nanjing, Jiangsu, China.
Yuxin LiuInstitute of Modern Biology, Department of Neurosurgery, Affiliated Nanjing Drum Tower Hospital, Nanjing University, Nanjing, Jiangsu, China.
Yujie WangInstitute of Modern Biology, Department of Neurosurgery, Affiliated Nanjing Drum Tower Hospital, Nanjing University, Nanjing, Jiangsu, China.
Ting KangInstitute of Modern Biology, Department of Neurosurgery, Affiliated Nanjing Drum Tower Hospital, Nanjing University, Nanjing, Jiangsu, China.
Xiaoming DaiInstitute of Modern Biology, Department of Neurosurgery, Affiliated Nanjing Drum Tower Hospital, Nanjing University, Nanjing, Jiangsu, China.ORCID 0000-0001-9671-8137
Jiong ChenMOE Key Laboratory of Model Animals for Disease Study, Jiangsu Key Laboratory of Molecular Medicine, Model Animal Research Center, Medical School of Nanjing University, Nanjing, Jiangsu, China.ORCID 0000-0001-5252-3936
Yuanming ChengInstitute of Modern Biology, Department of Hematology, Affiliated Nanjing Drum Tower Hospital, Nanjing University, Nanjing, Jiangsu, China. ymcheng@nju.edu.cn.
Liangqian HuangInstitute of Modern Biology, Department of Neurosurgery, Affiliated Nanjing Drum Tower Hospital, Nanjing University, Nanjing, Jiangsu, China. lqhuang@nju.edu.cn.ORCID 0000-0002-7146-0296

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32300651National Natural Science Foundation of China (National Science Foundation of China) 82370182
6 · The paper itself

Abstract

Proteostasis failure drives multiple neurodegenerative disorders (NDs), and ATP-independent chaperone pathways that support neuronal proteostasis remain poorly defined. Here, we identify the N6-methyladenosine (m

Indexed as

Amyotrophic Lateral SclerosisHeterogeneous Nuclear Ribonucleoprotein A1Molecular ChaperonesNerve Tissue ProteinsAnimalsHumansMutationNeuronsProtein AggregatesProtein Aggregation, PathologicalProtein FoldingHeterogeneous Nuclear Ribonucleoprotein A1hnRNPA1 protein, humanMolecular ChaperonesNerve Tissue ProteinsProtein Aggregates

Identifiers

PMID42680774
PMCPMC13534550

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.