Evidence map›Paper›PMID 42680743›Full record

ArticleNature communications2026

A potassium-based single-atom catalyst enables acute lung injury immunotherapy in mice by inhibiting macrophage pyroptosis.

Xiangyu Lu, Xuan Shi, Yanmin Jian, Cai Sun, Lijie Mao, Si Chen, Yuanru Zhao, Fang Huang, Ji Lu, Zhiyi Song and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Xiangyu Lu *Department of Anesthesiology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.ORCID 0000-0002-5606-894X
Xuan Shi *Department of Anesthesiology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Yanmin JianSchool of Materials Science and Engineering, Hainan University, Haikou, China.
Cai SunDepartment of Anesthesiology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Lijie MaoDepartment of Anesthesiology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Si ChenDepartment of Anesthesiology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Yuanru ZhaoDepartment of Anesthesiology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Fang HuangDepartment of Anesthesiology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Ji LuDepartment of Anesthesiology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Zhiyi SongDepartment of Anesthesiology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Guanning LiuDepartment of Anesthesiology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Xin LiSchool of Materials Science and Engineering, Hainan University, Haikou, China.
Yongjun ChenSchool of Materials Science and Engineering, Hainan University, Haikou, China.
Ke LiSchool of Materials Science and Engineering, Hainan University, Haikou, China. keli@hainanu.edu.cn.ORCID 0000-0002-2434-4954
Xin LvDepartment of Anesthesiology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China. xinlvg@126.com.ORCID 0000-0002-3352-7162
Jianlin ShiDepartment of Ophthalmology, Shanghai Tenth People's Hospital, Shanghai Frontiers Science Center of Nanocatalytic Medicine, Clinical Center For Brain And Spinal Cord Research, School of Medicine, Tongji University, Shanghai, China. jlshi@mail.sic.ac.cn.ORCID 0000-0001-8790-195X

Funding

National Natural Science Foundation of China (National Science Foundation of China) 52202352National Natural Science Foundation of China (National Science Foundation of China) 82372155Natural Science Foundation of Hainan Province 522MS038
6 · The paper itself

Abstract

Acute lung injury (ALI), which can have a mortality rate approaching 40%, lacks effective therapies. Macrophage pyroptosis represents a pro-inflammatory event and a potential therapeutic target. Here, we report a single-atom immunomodulator, a potassium-based single-atom catalyst (K-SAC) with K-N

Indexed as

Acute Lung InjuryImmunologic FactorsImmunotherapyMacrophagesPotassiumPyroptosisAnimalsCatalysisGasderminsHumansIntracellular Signaling Peptides and ProteinsLipopolysaccharidesMaleMiceMice, Inbred C57BLPhosphate-Binding ProteinsGasderminsGsdmd protein, mouseImmunologic FactorsIntracellular Signaling Peptides and ProteinsLipopolysaccharidesPhosphate-Binding ProteinsPotassiumReactive Oxygen SpeciesSuperoxide Dismutase

Identifiers

PMID42680743
PMCPMC13534642

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.