Evidence map›Paper›PMID 42680728›Full record

ArticleNature communications2026

Neonatal inflammation disrupts a temporally restricted postnatal Numb-enriched microglial state in mice.

Jinjin Zhu, Yiran Xu, Liubo Sun, Ziwei Huang, Wenkai Yu, Shan Zhang, Xiaoli Zhang, Tiantian He, Yiwen Chen, Yanan Wu and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jinjin Zhu *Henan Key Laboratory of Child Brain Injury, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Yiran Xu *Henan Key Laboratory of Child Brain Injury, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.ORCID 0000-0002-9004-0377
Liubo SunHenan Key Laboratory of Child Brain Injury, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Ziwei HuangHenan Key Laboratory of Child Brain Injury, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Wenkai YuHenan Key Laboratory of Child Brain Injury, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Shan ZhangHenan Key Laboratory of Child Brain Injury, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Xiaoli ZhangHenan Key Laboratory of Child Brain Injury, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Tiantian HeHenan Key Laboratory of Child Brain Injury, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Yiwen ChenHenan Key Laboratory of Child Brain Injury, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Yanan WuHenan Key Laboratory of Child Brain Injury, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Bingbing LiHenan Key Laboratory of Child Brain Injury, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Huifang DongHenan Key Laboratory of Child Brain Injury, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Xiaoyang WangHenan Key Laboratory of Child Brain Injury, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China. xiaoyang.wang@fysiologi.gu.se.ORCID 0000-0001-9717-8160
Changlian ZhuHenan Key Laboratory of Child Brain Injury, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China. changlian.zhu@neuro.gu.se.ORCID 0000-0002-5029-6730

Funding

National Natural Science Foundation of China (National Science Foundation of China) U21A20347Vetenskapsrådet (Swedish Research Council) 2022-01019
6 · The paper itself

Abstract

Early-life microglia are diverse and support brain development beyond immune surveillance, but the transient states associated with postnatal maturation remain poorly understood. Here we show, using a time-resolved single-cell atlas of neonatal mouse brain immune cells, that a postnatal Numb-enriched microglial state emerges during early postnatal development, expands during the second postnatal week and subsequently declines. This state is characterized by neurodevelopment-related gene expression programs and distinct metabolic features. Trajectory inference, cross-atlas mapping and RNAscope validation support its temporal pattern. During the period when this state expands, microglial depletion preserves gross myelination but alters synaptic protein composition and disrupts dendritic and cortical layer maturation, particularly in the primary somatosensory cortex. Neonatal lipopolysaccharide challenge impairs the establishment of the Numb-enriched state and induces an early glycolytic response followed by recovery-phase inflammatory states. These findings identify a developmentally timed microglial state associated with cortical maturation and vulnerable to neonatal inflammation in mice.

Indexed as

InflammationMembrane ProteinsMicrogliaNerve Tissue ProteinsAnimalsAnimals, NewbornBrainFemaleLipopolysaccharidesMaleMiceMice, Inbred C57BLNeurodevelopmentSomatosensory CortexLipopolysaccharidesMembrane ProteinsNerve Tissue ProteinsNumb protein, mouse

Identifiers

PMID42680728
PMCPMC13534487

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.