Evidence map›Paper›PMID 42680676›Full record

ReviewTrends in cancer2026

RBM15 in leukemogenesis: an emerging regulator at the interface of RNA biology and hematopoiesis.

Jether Amos Espinosa, Madeline Y Mayday, Abigail R Robb, Gina Lee, Diane S Krause

Abstract readReview
In one paragraph

Review in Trends in cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jether Amos EspinosaYale Stem Cell Center, Yale University School of Medicine, New Haven, CT, USA; Department of Pathology, Yale University School of Medicine, New Haven, CT, USA.
Madeline Y MaydayYale Stem Cell Center, Yale University School of Medicine, New Haven, CT, USA; Department of Pathology, Yale University School of Medicine, New Haven, CT, USA.
Abigail R RobbYale Stem Cell Center, Yale University School of Medicine, New Haven, CT, USA; Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA.
Gina LeeYale Stem Cell Center, Yale University School of Medicine, New Haven, CT, USA; Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT, USA.
Diane S KrauseYale Stem Cell Center, Yale University School of Medicine, New Haven, CT, USA; Department of Pathology, Yale University School of Medicine, New Haven, CT, USA; Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA. Electronic address: diane.krause@yale.edu.

Funding

Yale Cooperative Hematology Specialized Core CenterU54DK106857 · NIDDK · YALE UNIVERSITY · PI JOHN HWA, Diane S Krause · 2015 to 2026
$9.7M
Resource for Biocomputing Visualization and InformaticsP41GM103311 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2012 to 2017
$8.2M
IMMUNOHEMATOLOGY/TRANSFUSION MEDICINE RESEARCH TRAININGT32HL007974 · NHLBI · YALE UNIVERSITY · PI JEANNE E HENDRICKSON, Diane S Krause · 2001 to 2026
$8.1M
A generalizable framework for linking single-cell genomic states with cell fate outcomes in hematopoiesisRC2DK122376 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI GRIMES, H. LEIGHTON · 2020 to 2024
$5.3M
Mechanisms of Leukemogenesis in AMKLR01CA222518 · NCI · YALE UNIVERSITY · PI HALENE, STEPHANIE, KRAUSE, DIANE S · 2020 to 2024
$3.0M
Elucidation of the molecular mechanisms of the RBM15-MKL1 fusion protein in acute megakaryoblastic leukemiaF31CA271571 · NCI · YALE UNIVERSITY · PI Madeline Young Mayday · 2023 to 2026
$155k
Implicating the SPOC domain of RBM15 in RBM15::MKL1 fusion protein-induced acute megakaryoblastic leukemiaF31CA309946 · NCI · YALE UNIVERSITY · PI Jether Amos Sungduan Espinosa · 2026 to 2026
$35k
NCI NIH HHS F31 CA271571NCI NIH HHS F31 CA309946NCI NIH HHS R01 CA222518NHLBI NIH HHS T32 HL007974NIDDK NIH HHS RC2 DK122376NIDDK NIH HHS U54 DK106857NIGMS NIH HHS P41 GM103311
6 · The paper itself

Abstract

RNA-binding motif protein 15 (RBM15) is a key regulator of hematopoiesis and leukemogenesis, linking RNA metabolism, epitranscriptomic regulation, and lineage specification. Identified through the RBM15::MKL1 fusion in acute megakaryoblastic leukemia (AMKL), RBM15 functions within the N

Indexed as

epitranscriptomicshematopoiesisleukemogenesism(6)ARBM15RNA metabolism

Identifiers

PMID42680676
PMCPMC13596041

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.