ArticleJournal of Korean biological nursing science2026
The mediating effect of attitudes toward genetic testing on the relationship between genetic knowledge of familial hypercholesterolemia and the intention to undergo genetic testing among patients with hyperlipidemia in Korea: a cross-sectional study.
Article in Journal of Korean biological nursing science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeThis study examined whether attitudes toward genetic testing mediated the relationship between genetic knowledge of familial hypercholesterolemia (FH) and intention to undergo genetic testing among patients with hyperlipidemia.
methodsThis descriptive correlational, cross-sectional study included 140 adults with hyperlipidemia. Participants completed self-report questionnaires assessing genetic knowledge of FH, positive and negative attitudes toward genetic testing, and intention to undergo genetic testing. Data were analyzed using Pearson correlation analysis, multiple linear regression, and PROCESS Macro Model 4.
resultsMultiple regression analysis showed that family history in a sibling (β = .20, p = .011), positive attitudes toward genetic testing (β = .41, p < .001), and negative attitudes toward genetic testing (β = -.24, p = .006) were significantly associated with the intention to undergo genetic testing. While the total effect of genetic knowledge on the intention was not significant (BootB = 0.04, 95% confidence interval [CI] [-0.001, 0.081]), positive attitudes toward genetic testing significantly mediated the relationship between genetic knowledge of FH and the intention to undergo genetic testing (direct effect = 0.03, p = .177; indirect effect = 0.01, 95% CI [0.001, 0.031]). Negative attitudes toward genetic testing did not mediate the relationship.
conclusionPositive attitudes toward genetic testing were a significant mediator of the relationship between genetic knowledge of FH and intention to undergo genetic testing. These findings suggest that interventions intended to promote genetic testing should address patients' positive attitudes toward testing rather than rely solely on information provision.
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