Evidence map›Paper›PMID 42680200›Full record

ArticleGenes to cells : devoted to molecular & cellular mechanisms2026

The HMG-CoA Reductase Inhibitor Fluvastatin Promotes Th2-Skewed Immune Responses by Modulating Dendritic Cell Differentiation.

Satoshi Ishikawa, Haruka Mizuno, Kanon Murase, Kazuki Sasano, Isamu Ogawa, Yuka Itoh, Saotomo Itoh, Shigeaki Hida

Abstract read
In one paragraph

Article in Genes to cells : devoted to molecular & cellular mechanisms, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Satoshi IshikawaDepartment of Molecular and Cellular Health Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan.ORCID https://orcid.org/0009-0005-4433-0428
Haruka MizunoDepartment of Molecular and Cellular Health Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan.
Kanon MuraseDepartment of Molecular and Cellular Health Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan.
Kazuki SasanoDepartment of Molecular and Cellular Health Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan.
Isamu OgawaDepartment of Molecular and Cellular Health Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan.
Yuka ItohDepartment of Molecular and Cellular Health Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan.
Saotomo ItohLaboratory of Hygienic Chemistry, School of Pharmacy, Aichi Gakuin University, Nagoya, Japan.ORCID https://orcid.org/0000-0002-5704-0543
Shigeaki HidaDepartment of Molecular and Cellular Health Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan.ORCID https://orcid.org/0000-0003-4787-9430

Funding

Japan Science and Technology Agency JPMJSP2130
6 · The paper itself

Abstract

Statins, inhibitors of HMG-CoA reductase, exert immunomodulatory effects beyond lipid lowering, yet how they regulate T helper (Th) cell differentiation remains poorly understood. We show that fluvastatin administration to C57BL/6 mice for 7 days suppressed interferon-γ and elevated interleukin-4 production by splenic CD4

Indexed as

Cell DifferentiationDendritic CellsFatty Acids, MonounsaturatedHydroxymethylglutaryl-CoA Reductase InhibitorsIndolesTh2 CellsAnimalsFluvastatinGranulocyte-Macrophage Colony-Stimulating FactorInterferon-gammaInterleukin-4MiceMice, Inbred C57BLFatty Acids, MonounsaturatedFluvastatinGranulocyte-Macrophage Colony-Stimulating FactorHydroxymethylglutaryl-CoA Reductase InhibitorsIndolesInterferon-gammaInterleukin-4

Identifiers

PMID42680200
PMCPMC13533597

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.