Evidence map›Paper›PMID 42680102›Full record

ArticleThe Journal of biological chemistry2026

The BAIAP2 pathway regulates proliferation and migration in medulloblastoma.

Luz Clarita Ruiz, Rahul Patil, Stefania Mehedincu, Nitish Jangde, Robert K Suter, Anna M Jermakowicz, Jonathan Chu, Matthew D'Antuono, Eryn Nelson, Purushottam B Tiwari and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Luz Clarita RuizDepartment of Oncology, Georgetown University, Lombardi Comprehensive Cancer Center, Washington, District of Columbia, USA.
Rahul PatilDepartment of Biochemistry, Georgetown University, Washington, District of Columbia, USA.
Stefania MehedincuDepartment of Oncology, Georgetown University, Lombardi Comprehensive Cancer Center, Washington, District of Columbia, USA.
Nitish JangdeDepartment of Oncology, Georgetown University, Lombardi Comprehensive Cancer Center, Washington, District of Columbia, USA.
Robert K SuterDepartment of Oncology, Georgetown University, Lombardi Comprehensive Cancer Center, Washington, District of Columbia, USA.
Anna M JermakowiczDepartment of Oncology, Georgetown University, Lombardi Comprehensive Cancer Center, Washington, District of Columbia, USA.
Jonathan ChuDepartment of Oncology, Georgetown University, Lombardi Comprehensive Cancer Center, Washington, District of Columbia, USA.
Matthew D'AntuonoDepartment of Oncology, Georgetown University, Lombardi Comprehensive Cancer Center, Washington, District of Columbia, USA.
Eryn NelsonDepartment of Chemistry and Medicinal Chemistry Shared Resource Center, Georgetown University, Washington, District of Columbia, USA.
Purushottam B TiwariDepartment of Oncology, Georgetown University, Lombardi Comprehensive Cancer Center, Washington, District of Columbia, USA.
Christian WolfDepartment of Chemistry and Medicinal Chemistry Shared Resource Center, Georgetown University, Washington, District of Columbia, USA.
Aykut ÜrenDepartment of Oncology, Georgetown University, Lombardi Comprehensive Cancer Center, Washington, District of Columbia, USA.
Mi-Hye LeeDepartment of Oncology, Georgetown University, Lombardi Comprehensive Cancer Center, Washington, District of Columbia, USA.
Stella AlimpertiDepartment of Biochemistry, Georgetown University, Washington, District of Columbia, USA.
Nagi G AyadDepartment of Oncology, Georgetown University, Lombardi Comprehensive Cancer Center, Washington, District of Columbia, USA. Electronic address: na853@georgetown.edu.

Funding

Tissue Culture Shared ResourceP30CA051008 · NCI · GEORGETOWN UNIVERSITY · PI Louis M Weiner · 1990 to 2026
$71.5M
Epigenetic pathways and cell cycle exitR01NS118023 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI AYAD, NAGI G · 2020 to 2024
$1.8M
Biacore 4000 High Throughput SystemS10OD019982 · OD · GEORGETOWN UNIVERSITY · PI UREN, AYKUT · 2015 to 2015
$484k
Identification of BAIAP2 and CDC42 as potential therapeutic targets in SHH medulloblastomaF31CA291046 · NCI · GEORGETOWN UNIVERSITY · PI RUIZ, LUZ CLARITA · 2024 to 2025
$73k
NCI NIH HHS F31 CA291046NCI NIH HHS P30 CA051008NIH HHS S10 OD019982NINDS NIH HHS R01 NS118023
6 · The paper itself

Abstract

Medulloblastoma (MB) is the most common malignant pediatric brain tumor, with high rates of recurrence and resistance to standard-of-care therapy. Therefore, novel drugs are needed that target different aspects of MB biology, including the proliferative and migratory properties of tumor cells. Using bioinformatic approaches, we demonstrate that the cytoskeletal scaffolding protein BAIAP2 is differentially expressed in MB compared to nontumor brain cells, and that it is overexpressed in MB and metastatic MB tissue compared to normal cerebellum. BAIAP2 interacts with the Rho GTPases CDC42 and RAC1, which have known roles in migration and proliferation in multiple cell types. We demonstrate that BAIAP2 knockdown reduces migration and proliferation of MB cells. To characterize the BAIAP2 pathway further, we developed a small molecule screen using surface plasmon resonance (SPR) for compounds that bind BAIAP2. We discovered that the small molecule NSC678917 binds to BAIAP2 and inhibits MB cell proliferation and migration. Collectively, our studies suggest that the BAIAP2 pathway is a novel point of therapeutic intervention in MB.

Indexed as

BAIAP2CDC42medulloblastomamigrationproliferationRAC1

Identifiers

PMID42680102
PMCPMC13652964

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.