Evidence map›Paper›PMID 42679940›Full record

ArticleExperimental neurology2027

Therapeutic hypothermia does not prevent dysmaturity of medial ganglionic eminence-derived interneurons in the dorsal hippocampus after neonatal hypoxia-ischemia.

Harisa Spahic, Mark St Pierre, Pritika Parmar, Daniel Severin de la Plaza, Nivriti Vanga, Alexandria Whitley, Michael Nugent, Alfredo Kirkwood, Raul Chavez-Valdez

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In one paragraph

Article in Experimental neurology, 2027. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Harisa SpahicDepartment of Pediatrics, Division of Neonatology, Johns Hopkins University, Baltimore, MD, USA.
Mark St PierreDepartment of Pediatrics, Division of Neonatology, Johns Hopkins University, Baltimore, MD, USA.
Pritika ParmarDepartment of Pediatrics, Division of Neonatology, Johns Hopkins University, Baltimore, MD, USA.
Daniel Severin de la PlazaDepartment of Neuroscience, Johns Hopkins University, Baltimore, MD, USA.
Nivriti VangaDepartment of Pediatrics, Division of Neonatology, Johns Hopkins University, Baltimore, MD, USA.
Alexandria WhitleyDepartment of Pediatrics, Division of Neonatology, Johns Hopkins University, Baltimore, MD, USA.
Michael NugentDepartment of Pediatrics, Division of Neonatology, Johns Hopkins University, Baltimore, MD, USA.
Alfredo KirkwoodDepartment of Neuroscience, Johns Hopkins University, Baltimore, MD, USA.
Raul Chavez-ValdezDepartment of Pediatrics, Division of Neonatology, Johns Hopkins University, Baltimore, MD, USA; Neuroscience Intensive Care Nursery Program, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD, USA. Electronic address: rchavez2@jhmi.edu.

Funding

Advanced therapeutic hypothermia efficacy network modeling in neonatal HIER01HD110091 · NICHD · JOHNS HOPKINS UNIVERSITY · PI EVERETT, ALLEN D, NORTHINGTON, FRANCES J · 2022 to 2025
$2.7M
Precision Medicine for Neonatal Hypoxic-Ischemic Encephalopathy: Combined Neuroimaging Clinical Approach to Link Phenotypes to PrognosisR01NS126549 · NINDS · JOHNS HOPKINS UNIVERSITY · PI Kenichi Oishi · 2022 to 2026
$2.0M
NICHD NIH HHS R01 HD110091NINDS NIH HHS R01 NS126549
6 · The paper itself

Abstract

introductionNeonatal hypoxic-ischemic (HI) brain injury results in a persistent deficit of hippocampal parvalbumin (PV)

methodsFollowing HI at P10, mice were randomized to normothermia (36 °C, NT) or hypothermia (31 °C, TH) with anesthesia-exposed littermates as shams. Hippocampus was evaluated at P11, P18, and P40 for PV, SST, SAtb1, GFAP, Kv3.1b, and Kv3.2 (IF-IHC), electrical phenotyping and mIPSC (patch clamping), and RNA (real time RT PCR) and protein (western blot). Y-maze task and open field were performed for the P40 cohort.

resultsThe number of SAtb1

conclusionsNeonatal HI brain injury leads to dysmature GE-derived INs in the hippocampus, which persists to adulthood and not prevented by TH. Surviving GE-derived SAtb1

Indexed as

Ganglionic EminenceHippocampusHypothermia, InducedHypoxia-Ischemia, BrainInterneuronsAnimalsAnimals, NewbornMaleMiceMice, Inbred C57BLHypoxic-ischemicInterneuronsParvalbuminSAtb1SomatostatinTherapeutic hypothermia

Identifiers

PMID42679940
PMCPMC13644577

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.