Evidence map›Paper›PMID 42679899›Full record

ArticleThe American journal of clinical nutrition2026

Serum-based biomarker development for dietary macronutrient densities and their association with breast and colorectal cancer risk in a cohort of postmenopausal females.

Ross L Prentice, Aaron K Aragaki, Johanna W Lampe, Marian L Neuhouser, JoAnn E Manson, Daniel Raftery, Ga Nagana Gowda, Ying Huang, Lesley F Tinker, Sandi L Navarro and 2 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of clinical nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00000611 (Women's Health Initiative), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00000611 phase3completednot on this map

Women's Health Initiative (WHI)

TypeinterventionalSponsorNational Heart, Lung, and Blood Institute (NHLBI)ConditionsBone Diseases, Breast Neoplasms, Cardiovascular Diseases, Colonic NeoplasmsArmshormone replacement therapy, estrogens, progestins, estrogen replacement therapy, diet, fat-restricted
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ross L PrenticeDivision of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, United States; School of Public Health, University of Washington, Seattle, WA, United States. Electronic address: rprentic@whi.org.
Aaron K AragakiDivision of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, United States.
Johanna W LampeDivision of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, United States; School of Public Health, University of Washington, Seattle, WA, United States.
Marian L NeuhouserDivision of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, United States; School of Public Health, University of Washington, Seattle, WA, United States.
JoAnn E MansonBrigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Daniel RafteryDepartment of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, United States.
Ga Nagana GowdaDepartment of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, United States.
Ying HuangDivision of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, United States; School of Public Health, University of Washington, Seattle, WA, United States.
Lesley F TinkerDivision of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, United States.
Sandi L NavarroDivision of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, United States.
Dorothy S LaneRenaissance School of Medicine, Stony Brook University, Stony Brook, NY, United States.
Cheng ZhengDepartment of Biostatistics, University of Nebraska Medical Center, Omaha, NE, United States.

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Marian Esvelt · 1985 to 2026
$296.4M
PILOT STUDY--CLINICAL NUTRITION RESEARCHP30DK035816 · NIDDK · UNIVERSITY OF WASHINGTON · PI Ellen A Schur · 1986 to 2026
$30.4M
Nutrition and Physical Activity Assessment Study (NPAAS)R01CA119171 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Marian L Neuhouser · 2006 to 2026
$14.3M
NCI NIH HHS P30 CA015704NCI NIH HHS R01 CA119171NIDDK NIH HHS P30 DK035816
6 · The paper itself

Abstract

backgroundAssociations of the macronutrient composition of the diet with risks of postmenopausal breast and colorectal cancer (CRC) are uncertain, partly because of reliance on self-reported dietary data.

objectivesThis study aims to study biomarker development for several macronutrient component densities using serum and spot urine metabolomics and, when appropriate, to assess their associations with breast cancer and CRC risks in a Women's Health Initiative (WHI) cohort of postmenopausal United States females.

methodsWe explored linear biomarker equations for log-transformed macronutrient component densities using fasting serum metabolomic profiles, with and without spot urine, in a WHI feeding study (n = 153). We used equations satisfying a cross-validated regression R

resultsSerum-based biomarker equations for macronutrient component densities had CV-R

conclusionsIn a population of United States postmenopausal females, dietary MUFA density was associated with an elevation in CRC risk. Breast cancer associations with biomarker-based macronutrient densities require further development. This trial was registered at clinicaltrials.gov as NCT00000611 (https://clinicaltrials.gov/study/NCT00000611).

Indexed as

Breast NeoplasmsColorectal NeoplasmsDietNutrientsPostmenopauseAgedBiomarkersClinical Trials, Phase III as TopicCohort StudiesDietary FatsFemaleHumansMiddle AgedRandomized Controlled Trials as TopicRisk FactorsBiomarkersDietary Fatsbiomarkerbreast cancercolorectal cancerdietary assessmentmacronutrient densitymetabolomicsserumspot urine

Identifiers

PMID42679899
PMCPMC13679899

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.