Evidence map›Paper›PMID 42679897›Full record

ArticleTumour virus research2026

IL-33/IL1RL1 (ST2) signalling drives immune suppression in squamous intraepithelial hyperplasia.

Chenhao Zhou, Jazmina Gonzalez Cruz, Siok Min Teoh, Minh Tran, Denise Goh, Divyaa Narayanan, Xiao Tan, Thi Viet Trinh Dang, Zewen Kelvin Tuong, Kevin Gillinder and 7 more

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Article in Tumour virus research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Chenhao ZhouFrazer Institute, Faculty of Health, Medicine, and Behavioural Sciences, The University of Queensland, Brisbane, Queensland, 4102, Australia; Dermatology Research Centre, The University of Queensland, Brisbane, Queensland, 4102, Australia.
Jazmina Gonzalez CruzFrazer Institute, Faculty of Health, Medicine, and Behavioural Sciences, The University of Queensland, Brisbane, Queensland, 4102, Australia; Dermatology Research Centre, The University of Queensland, Brisbane, Queensland, 4102, Australia.
Siok Min TeohFrazer Institute, Faculty of Health, Medicine, and Behavioural Sciences, The University of Queensland, Brisbane, Queensland, 4102, Australia.
Minh TranInstitute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland, 4067, Australia.
Denise GohFrazer Institute, Faculty of Health, Medicine, and Behavioural Sciences, The University of Queensland, Brisbane, Queensland, 4102, Australia.
Divyaa NarayananFrazer Institute, Faculty of Health, Medicine, and Behavioural Sciences, The University of Queensland, Brisbane, Queensland, 4102, Australia.
Xiao TanInstitute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland, 4067, Australia; QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Thi Viet Trinh DangFrazer Institute, Faculty of Health, Medicine, and Behavioural Sciences, The University of Queensland, Brisbane, Queensland, 4102, Australia.
Zewen Kelvin TuongFrazer Institute, Faculty of Health, Medicine, and Behavioural Sciences, The University of Queensland, Brisbane, Queensland, 4102, Australia.
Kevin GillinderFrazer Institute, Faculty of Health, Medicine, and Behavioural Sciences, The University of Queensland, Brisbane, Queensland, 4102, Australia.
Abate BashawFrazer Institute, Faculty of Health, Medicine, and Behavioural Sciences, The University of Queensland, Brisbane, Queensland, 4102, Australia.
James W WellsFrazer Institute, Faculty of Health, Medicine, and Behavioural Sciences, The University of Queensland, Brisbane, Queensland, 4102, Australia; Dermatology Research Centre, The University of Queensland, Brisbane, Queensland, 4102, Australia.
Ian H FrazerFrazer Institute, Faculty of Health, Medicine, and Behavioural Sciences, The University of Queensland, Brisbane, Queensland, 4102, Australia.
Quan NguyenInstitute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland, 4067, Australia; QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Yu ChenMaterdicine Lab, School of Life Sciences, Shanghai University, Shanghai, 200444, PR China. Electronic address: chenyuedu@shu.edu.cn.
Meihua YuFrazer Institute, Faculty of Health, Medicine, and Behavioural Sciences, The University of Queensland, Brisbane, Queensland, 4102, Australia; Materdicine Lab, School of Life Sciences, Shanghai University, Shanghai, 200444, PR China. Electronic address: m.yu2@uq.edu.au.
Janin ChandraFrazer Institute, Faculty of Health, Medicine, and Behavioural Sciences, The University of Queensland, Brisbane, Queensland, 4102, Australia; Dermatology Research Centre, The University of Queensland, Brisbane, Queensland, 4102, Australia. Electronic address: j.chandra@uq.edu.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

IL-33, an alarmin cytokine binding to IL1RL1 (ST2) receptor, plays a multifaceted role in cancer. Using an HPV16-E7 oncoprotein-mediated murine model of squamous intraepithelial hyperplasia, a pre-stage of squamous cell carcinoma (SCC), we characterised the interactions of hyperproliferative epithelial cells and immune cells regulated by IL-33 and IL1RL1. We show that basal epithelial cells in epithelial hyperplasia co-express IL-33 and genes involved in MHC class II antigen presentation and in epithelial stress response. Using spatial transcriptomics, we demonstrate that IL1RL1

Identifiers

PMID42679897
PMCPMC13579448

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.