Evidence map›Paper›PMID 42679819›Full record

ArticleCell2026

Cross-species single-cell atlas of the striatum defines cell-type and subregion disease vulnerabilities.

Raleigh M Linville, Benjamin T James, Kyriaki Galani, Li-Lun Ho, Jung Hoon Shin, Esaria Oliver, Stuart B Fass, James C Cameron, Brent E Fitzwalter, Roland Bock and 19 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Raleigh M LinvilleThe Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; The Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA.
Benjamin T JamesThe Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA; Computer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, 32 Vassar St, Cambridge, MA 02139, USA.
Kyriaki GalaniThe Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA; Computer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, 32 Vassar St, Cambridge, MA 02139, USA.
Li-Lun HoComputer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, 32 Vassar St, Cambridge, MA 02139, USA.
Jung Hoon ShinLaboratory on Neurobiology of Compulsive Behaviors, NIMH, NIAAA, National Institutes of Health, Bethesda, MD 20892, USA.
Esaria OliverCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Stuart B FassComputer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, 32 Vassar St, Cambridge, MA 02139, USA.
James C CameronThe Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
Brent E FitzwalterThe Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Roland BockLaboratory on Neurobiology of Compulsive Behaviors, NIMH, NIAAA, National Institutes of Health, Bethesda, MD 20892, USA.
Erin M MurrayLaboratory on Neurobiology of Compulsive Behaviors, NIMH, NIAAA, National Institutes of Health, Bethesda, MD 20892, USA.
Mathilde LouçãCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Oluwamayowa OkeThe Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Charlotte WangThe Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
Erica Engelberg-CookDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Michael DeTureDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Vanessa FarrellThe Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Sergio Sebastian PinedaThe Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; The Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA; Computer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, 32 Vassar St, Cambridge, MA 02139, USA.
Suphinya SathitloetsakunThe Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Xinyue LiangThe Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Bertha MadrasDepartment of Psychiatry, Harvard Medical School, Boston, MA, USA; McLean Hospital, Belmont, MA 02478, USA.
Dennis W DicksonDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Deborah C MashDepartment of Population Health Sciences, Patel College of Allopathic Medicine, Nova Southeastern University, Fort Lauderdale, FL, USA.
Gustavo TureckiMcGill Group for Suicide Studies, Douglas Hospital Research Center, Verdun, QC, Canada; Integrated Program in Neuroscience, McGill University, Montreal, QC, Canada; Department of Psychiatry, McGill University, Montreal, QC, Canada.
Vanessa C WheelerCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Veronica A AlvarezLaboratory on Neurobiology of Compulsive Behaviors, NIMH, NIAAA, National Institutes of Health, Bethesda, MD 20892, USA.
Dana GabuzdaDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Neurology, Harvard Medical School, Boston, MA, USA. Electronic address: dana_gabuzda@dfci.harvard.edu.
Manolis KellisThe Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA; Computer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, 32 Vassar St, Cambridge, MA 02139, USA. Electronic address: manoli@mit.edu.
Myriam HeimanThe Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA. Electronic address: mheiman@mit.edu.

Funding

The Manhattan HIV Brain BankU24MH100931 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MORGELLO, SUSAN · 2013 to 2023
$14.0M
Single Cell Transcriptomic and Epigenomic Dissection of Opioid and Cocaine Responses in HIVU01DA053631 · NIDA · BROAD INSTITUTE, INC. · PI HEIMAN, MYRIAM, KELLIS, MANOLIS · 2021 to 2025
$12.6M
Texas NeuroAIDS Research CenterU24MH100930 · NIMH · UNIVERSITY OF TEXAS MED BR GALVESTON · PI GELMAN, BENJAMIN B. · 2013 to 2023
$12.1M
DATA COORDINATING CENTER TO PROVIDE SERVICES TO WORK COLLABORATIVELY WITH THE NATIONAL NEUROHIV TISSUE CONSORTIUM CLINICAL SITES TO PROVIDE MANAGEMENT AND DATABASE CAPABILITIES, SCIENTIFIC EXPERTISE, 75N95023C00013 · NIDA · THE EMMES COMPANY, LLC · PI SHERMAN, SETH · 2023 to 2025
$11.2M
Huntington's Disease Repeat Instability and PathogenesisR01NS049206 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI VANESSA C WHEELER · 2005 to 2026
$10.0M
Mapping the vulnerable locus coeruleus pathways in aging and ADU01AG077227 · NIA · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Kwanghun Chung, Li-Huei Tsai · 2022 to 2026
$9.6M
NNTC Data Coordinating CenterU24MH100925 · NIMH · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI FOX, HOWARD S, SHERMAN, SETH · 2013 to 2022
$9.5M
Identification of TDP-43 Modifiers Through Single-Cell Transcriptional and Epigenomic Dissection of ALS and FTLD-MNDR01NS127187 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BELZIL, VERONIQUE, DONNELLY, CHRISTOPHER JAMES · 2021 to 2025
$9.1M
THE NNTC COLLECTS, STORE, AND PROVIDE CLINICAL DATA AND WELL CHARACTERIZED BIOLOGICAL SPECIMENS, INCLUDING POST-MORTEM TISSUE FROM STUDY VOLUNTEERS AND/OR ORGAN DONORS WITH HIV AS WELL AS HIV-NEGATIVE75N95023C00015 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HADIJAH, VACTOR · 2023 to 2025
$9.0M
Epigenomic, transcriptional and cellular dissection of Alzheimer's variantsR01AG058002 · NIA · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI HYMAN, BRADLEY T., JAENISCH, RUDOLF · 2017 to 2021
$7.9M
Elucidating the Molecular Mechanisms of Neuropsychiatric Symptoms in Alzheimer's DiseaseR01AG062335 · NIA · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI KELLIS, MANOLIS, TSAI, LI-HUEI · 2018 to 2022
$6.5M
Single-cell epigenomic and trancriptional dissection of sex-specific differences in Alzheimer’s DiseaseR01AG074003 · NIA · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI KELLIS, MANOLIS, TSAI, LI-HUEI · 2021 to 2025
$5.4M
NHGRI NIH HHS R01 HG008155NHGRI NIH HHS U01 HG012009NIA NIH HHS R01 AG058002NIA NIH HHS R01 AG062335NIA NIH HHS R01 AG067151NIA NIH HHS R01 AG074003NIA NIH HHS R01 AG081017NIA NIH HHS RF1 AG054012NIA NIH HHS RF1 AG062377NIA NIH HHS U01 AG077227NIDA NIH HHS 75N95023C00013NIDA NIH HHS 75N95023C00015NIDA NIH HHS 75N95023C00016NIDA NIH HHS R01 DA054584NIDA NIH HHS R01 DA063327NIDA NIH HHS U01 DA053631NIH HHS 75N95023C00015NIMH NIH HHS R01 MH109978NIMH NIH HHS U01 MH119509NIMH NIH HHS U24 MH100925NIMH NIH HHS U24 MH100930NIMH NIH HHS U24 MH100931NINDS NIH HHS F32 NS128067NINDS NIH HHS R01 NS049206NINDS NIH HHS R01 NS127187NINDS NIH HHS R35 NS127327NINDS NIH HHS RF1 NS129032NINDS NIH HHS U01 NS110453NINDS NIH HHS UH3 NS115064
6 · The paper itself

Abstract

The striatum is critical for decision-making, movement, and reward processing, functions achieved through subregional cellular and molecular specialization. Striatal cell types and subregions are differentially implicated in neurodegenerative and neuropsychiatric disorders, but the mechanisms underlying these vulnerabilities are poorly understood. Using single-nucleus RNA sequencing across 109 human and 22 mouse samples spanning dorsal and ventral striatum, we provide a comprehensive atlas of subregional neuronal specialization. We define rare neuronal subpopulations and transcriptional gradients along the dorsolateral-ventromedial axis with notable differences between species, suggesting divergent pharmacological targets, connectivity, and disease mechanisms. Integration with genome-wide association and pharmacological studies identifies human-enriched sites of opioid receptor expression and ventral-biased chronic antipsychotic action. Lastly, paired single-cell transcriptomic and somatic trinucleotide repeat expansion measurements identify differences in subregion and neuronal subtype vulnerability in Huntington's disease. Our findings lay the foundation for understanding how striatal cell types and subregions contribute to brain function and neurological disorders.

Indexed as

Corpus StriatumSingle-Cell AnalysisAnimalsGenome-Wide Association StudyHumansHuntington DiseaseMaleMedium Spiny NeuronsMiceNeuronsReceptors, OpioidSingle-Cell Gene Expression AnalysisSpecies SpecificityTranscriptomeTrinucleotide Repeat ExpansionReceptors, Opioidantipsychoticscross-species comparisonHuntington’s diseasemedium spiny neuronsopioid receptorsrepeat instabilitysingle-cell RNA sequencingspatial transcriptomicsstriatum

Identifiers

PMID42679819
PMCPMC13653636

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.