A designer saxitoxin-engineered sodium channel pair as a general tool for subtype-selective inhibition.

Elizabeth R Park, Nicholas Denomme, Holly S Hajare, J Du Bois

Abstract read

In one paragraph

Article in Cell chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Elizabeth R ParkDepartment of Chemistry, Stanford University, Stanford, CA 94305, USA.

Nicholas DenommeNancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.

Holly S HajareDepartment of Chemistry, Stanford University, Stanford, CA 94305, USA.

J Du BoisDepartment of Chemistry, Stanford University, Stanford, CA 94305, USA. Electronic address: jdubois@stanford.edu.

Funding

Guanidinium Toxins as Molecular Probes for NaV StudyR01GM117263 · NIGMS · STANFORD UNIVERSITY · PI DU BOIS, JUSTIN · 2016 to 2024

$3.5M

Stanford Chem-H Chemistry/Biology Interface Predoctoral Training ProgramT32GM120007 · NIGMS · STANFORD UNIVERSITY · PI BERTOZZI, CAROLYN · 2016 to 2020

$1.2M

NIGMS NIH HHS R01 GM117263NIGMS NIH HHS T32 GM120007

6 · The paper itself

Abstract

We have used small molecule chemical design and protein engineering to fashion an orthogonal ligand-channel pair that enables acute and selective inhibition of a genetically encoded voltage-gated sodium channel (Na

Indexed as

Drug DesignProtein EngineeringSaxitoxinVoltage-Gated Sodium Channel BlockersVoltage-Gated Sodium ChannelsAnimalsHEK293 CellsHumansLigandsLigandsSaxitoxinVoltage-Gated Sodium Channel BlockersVoltage-Gated Sodium Channelschemogeneticsdesigner ligandelectrophysiologyprotein mutagenesisvoltage-gated sodium channel

Identifiers

PMID42679814

DOI10.1016/j.chembiol.2026.05.016

PMCPMC13537208

What OpenQuestion holds

Textmetadata

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.