Phosphorescence lifetime microscopy and contrast-enhanced ultrasound imaging revealed strong left-to-right intraventricular shunt in anesthetized Xenopus laevis.

Ken Hashimoto, Momoko Ohira, Misaki Kimoto, Akiko Oda, Kosuke Tsukada, Akira Hanashima, Satoshi Mohri

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Article in The journal of physiological sciences : JPS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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7 authors.

Ken HashimotoFirst Department of Physiology, Kawasaki Medical School, Kurashiki 701-0192, Japan. Electronic address: khashimo@med.kawasaki-m.ac.jp.

Momoko OhiraFirst Department of Physiology, Kawasaki Medical School, Kurashiki 701-0192, Japan.

Misaki KimotoFirst Department of Physiology, Kawasaki Medical School, Kurashiki 701-0192, Japan.

Akiko OdaFirst Department of Physiology, Kawasaki Medical School, Kurashiki 701-0192, Japan.

Kosuke TsukadaDepartment of Applied Physics and Physico-Informatics, Keio University, Yokohama 223-8522, Japan.

Akira HanashimaFirst Department of Physiology, Kawasaki Medical School, Kurashiki 701-0192, Japan.

Satoshi MohriFirst Department of Physiology, Kawasaki Medical School, Kurashiki 701-0192, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amphibians exhibit intracardiac shunting, by which oxygen from multiple respiratory surfaces is variably distributed between systemic and pulmonary circulations. Although shunting has been extensively studied in terrestrial species that rely heavily on pulmonary respiration, much less is known about more aquatic, cutaneous-respiring species, in which cutaneously oxygenated blood returns to the right atrium, so the right-left oxygen gradient should vary with context. Moreover, the proposed role of ventricular trabeculation in limiting intraventricular mixing has not been directly demonstrated. We combined phosphorescence lifetime microscopy for in vivo pO

Indexed as

AmphibianContrast-enhanced ultrasoundIntracardiac shuntPhosphorescence lifetime microscopy

Identifiers

PMID42679731

DOI10.1016/j.jphyss.2026.100098

PMCPMC13570341

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