Evidence map›Paper›PMID 42679720›Full record

ArticlePoultry science2026

Silphium perfoliatum flavonoids alleviate LPS-induced injury via enhancing intestinal antioxidant capacity, barrier function, and regulating cecal microbiota in broilers.

Guanglong Liu, Wei Guo, Tengyuqi Li, Yuhan Wang, Kabelo Anthony Makatjane, Hongzhi Lin, Jiayin Xu, Fang Zhang, Haizhu Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Poultry science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Guanglong LiuCollege of Animal Science and Technology, Jilin Agricultural University, Changchun, Jilin Province, China.
Wei GuoJilin Provincial Animal Husbandry General Station, Changchun, Jilin Province, China.
Tengyuqi LiCollege of Animal Science and Technology, Jilin Agricultural University, Changchun, Jilin Province, China.
Yuhan WangCollege of Animal Science and Technology, Jilin Agricultural University, Changchun, Jilin Province, China.
Kabelo Anthony MakatjaneCollege of Animal Science and Technology, Jilin Agricultural University, Changchun, Jilin Province, China; Department of Animal Science, Faculty of Agriculture, National University of Lesotho, Roma 180, Maseru, Lesotho.
Hongzhi LinCollege of Animal Science and Technology, Jilin Agricultural University, Changchun, Jilin Province, China.
Jiayin XuCollege of Animal Science and Technology, Jilin Agricultural University, Changchun, Jilin Province, China.
Fang ZhangCollege of Animal Science and Technology, Jilin Agricultural University, Changchun, Jilin Province, China.
Haizhu ZhouCollege of Animal Science and Technology, Jilin Agricultural University, Changchun, Jilin Province, China. Electronic address: zhouhaizhu@jlau.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigated the effects of Silphium perfoliatum L. flavonoids (SPF) on growth performance, intestinal morphology, antioxidant capacity, anti-inflammatory responses, gut barrier function, and cecal microbiota in lipopolysaccharide (LPS)-challenged broilers. 250 one-day-old Arbor Acres broilers were randomly assigned to five groups: control (C), LPS (L), and LPS + SPF at 100, 200, or 300 mg/kg (SL1, SL2, SL3), with five replicates of 10 birds. Broilers in the LPS and SPF groups received 0.5 mg/kg LPS intraperitoneally on days 16, 18, and 20, while the control group received an equal volume of saline. SPF mitigated LPS-induced growth impairment, reducing feed-to-gain ratio (F/G) and improving average daily gain (ADG), villus height (VH), and villus height to crypt depth ratio (VH/CD) relative to the LPS group (all P < 0.001). SPF supplementation decreased malondialdehyde (MDA, P < 0.001), increased glutathione peroxidase (GSH-Px, P < 0.001) and total superoxide dismutase (T-SOD, P = 0.011), elevated interleukin-4 (IL-4, P = 0.03), enhanced interleukin-10 (IL-10, P < 0.001), and reduced tumor necrosis factor-α (TNF-α, P < 0.001). SPF downregulated jejunal Toll-like receptor 4 (TLR4), myeloid differentiation factor 88 (MyD88), nuclear factor kappa-B (NF-κB), and TNF-α mRNA expression (all P < 0.001) and upregulated tight junction genes zonula occludens-1 (ZO-1) and occludin (OCLN, both < 0.001), and claudin-1 (CLDN1, P = 0.002). SPF ameliorated LPS-induced decreases in cecal microbial diversity and abundances of beneficial bacteria including Lactobacillus and Ruminococcus. These results indicate that dietary SPF effectively improves growth, gut health, antioxidant status, and anti-inflammatory responses in LPS-stressed broilers, supporting its potential as a natural alternative to antibiotics in poultry production.

Indexed as

Antioxidant capacityGut barrier functionMicrobial diversityOxidative stressTLR4/MyD88/NF-κB

Identifiers

PMID42679720
PMCPMC13570360

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.