Evidence map›Paper›PMID 42679687›Full record

ArticleDrug metabolism and disposition: the biological fate of chemicals2026

Effects of simulated exogenous and endogenous lipid microenvironments on cannabidiol disposition and cytochrome P450 2C19-mediated drug interactions: New mechanistic insights.

Aiden-Hung P Nguyen, Fridah C Rotich, Nadja B Cech, Mary F Paine

Abstract read
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In one paragraph

Article in Drug metabolism and disposition: the biological fate of chemicals, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Aiden-Hung P NguyenDepartment of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington.
Fridah C RotichDepartment of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina.
Nadja B CechDepartment of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina; Center of Excellence for Natural Product Drug Interaction Research, Spokane, Washington.
Mary F PaineDepartment of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington; Center of Excellence for Natural Product Drug Interaction Research, Spokane, Washington. Electronic address: mary.paine@wsu.edu.

Funding

Pharmacology CoreU54AT008909 · NCCIH · WASHINGTON STATE UNIVERSITY · PI BOYCE, RICHARD DAVID · 2015 to 2024
$22.4M
NCCIH NIH HHS U54 AT008909
6 · The paper itself

Abstract

Cannabidiol (CBD) is an in vitro inhibitor of multiple cytochrome P450 (P450) enzymes, which has been confirmed in healthy adults. Whether these observations translate to different patient populations, including those with hepatic steatosis, is not known. Accordingly, the effects of simulated exogenous and endogenous lipid microenvironments on the P450 inhibition potential and disposition of CBD were evaluated using human liver microsomes (HLMs). Consistent with clinical observations, CYP2C19 was most sensitive to inhibition by CBD as both a component of a mixture containing triglycerides (CBD

Indexed as

CannabidiolCytochrome P-450 CYP2C19Cytochrome P-450 CYP2C19 InhibitorsDrug InteractionsFatty AcidsFatty LiverHumansLipid MetabolismMicrosomes, LiverTriglyceridesCannabidiolCYP2C19 protein, humanCytochrome P-450 CYP2C19Cytochrome P-450 CYP2C19 InhibitorsFatty AcidsTriglyceridesCannabidiolCytochrome P450Drug interactionHepatic steatosisHuman liver microsomesInhibition

Identifiers

PMID42679687
PMCPMC13688994

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.