Evidence map›Paper›PMID 42679158›Full record

ArticleJournal of medicinal chemistry2026

A 16 × 8 Focused Compound Library Comprising All Configurational Isomers of the Archetypal Iminosugar, 1-Deoxynojirimycin.

Richard J B H N van den Berg, Adrianus M C H van den Nieuwendijk, Bing Liu, Maria J Ferraz, Cecile M J Ouairy, Amar T Ghisaidoobe, Qiang Ma, Hans van den Elst, Anneke Strijland, Wilma E Donker-Koopman and 9 more

Abstract read
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Article in Journal of medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Richard J B H N van den BergGorlaeus Laboratories, Leiden Institute of Chemistry, Einsteinweg 55, Leiden2333 CC, The Netherlands.
Adrianus M C H van den NieuwendijkGorlaeus Laboratories, Leiden Institute of Chemistry, Einsteinweg 55, Leiden2333 CC, The Netherlands.
Bing LiuGorlaeus Laboratories, Leiden Institute of Chemistry, Einsteinweg 55, Leiden2333 CC, The Netherlands.
Maria J FerrazGorlaeus Laboratories, Leiden Institute of Chemistry, Einsteinweg 55, Leiden2333 CC, The Netherlands.
Cecile M J OuairyGorlaeus Laboratories, Leiden Institute of Chemistry, Einsteinweg 55, Leiden2333 CC, The Netherlands.
Amar T GhisaidoobeGorlaeus Laboratories, Leiden Institute of Chemistry, Einsteinweg 55, Leiden2333 CC, The Netherlands.
Qiang MaGorlaeus Laboratories, Leiden Institute of Chemistry, Einsteinweg 55, Leiden2333 CC, The Netherlands.
Hans van den ElstGorlaeus Laboratories, Leiden Institute of Chemistry, Einsteinweg 55, Leiden2333 CC, The Netherlands.
Anneke StrijlandGorlaeus Laboratories, Leiden Institute of Chemistry, Einsteinweg 55, Leiden2333 CC, The Netherlands.
Wilma E Donker-KoopmanGorlaeus Laboratories, Leiden Institute of Chemistry, Einsteinweg 55, Leiden2333 CC, The Netherlands.
Marri VerhoekGorlaeus Laboratories, Leiden Institute of Chemistry, Einsteinweg 55, Leiden2333 CC, The Netherlands.
Koen J RijpkemaGorlaeus Laboratories, Leiden Institute of Chemistry, Einsteinweg 55, Leiden2333 CC, The Netherlands.
Rolf G BootGorlaeus Laboratories, Leiden Institute of Chemistry, Einsteinweg 55, Leiden2333 CC, The Netherlands.
Tom WennekesGorlaeus Laboratories, Leiden Institute of Chemistry, Einsteinweg 55, Leiden2333 CC, The Netherlands.ORCID 0000-0002-2368-7728
Gijsbert A van der MarelGorlaeus Laboratories, Leiden Institute of Chemistry, Einsteinweg 55, Leiden2333 CC, The Netherlands.
Constant A A van BoeckelGorlaeus Laboratories, Leiden Institute of Chemistry, Einsteinweg 55, Leiden2333 CC, The Netherlands.
Marta ArtolaGorlaeus Laboratories, Leiden Institute of Chemistry, Einsteinweg 55, Leiden2333 CC, The Netherlands.ORCID 0000-0002-3051-3902
Johannes M F G AertsGorlaeus Laboratories, Leiden Institute of Chemistry, Einsteinweg 55, Leiden2333 CC, The Netherlands.ORCID 0000-0001-8168-2565
Herman S OverkleeftGorlaeus Laboratories, Leiden Institute of Chemistry, Einsteinweg 55, Leiden2333 CC, The Netherlands.ORCID 0000-0001-6976-7005

Funding

China Scholarship Council NAEuropean Research Council 290836Nederlandse Organisatie voor Wetenschappelijk Onderzoek 2018-714.018.002
6 · The paper itself

Abstract

Deoxynojirimycin is the archetypal iminosugar, from which many structural and configurational isosteres have been derived and studied in past decades. In total, 16 configurational isomers of deoxynojirimycin exist, but these have not yet been collected in a single library. This paper describes the assembly of such a library with each configurational isomer present in eight N-substituted forms. Screening of this library against the three glucosylceramide processing enzymes, glucosylceramide synthase (GCS), lysosomal glucosylceramidase (GBA1), and nonlysosomal glucosylceramidase (GBA2), confirms earlier data that appropriately substituted D-Glc, D-Gal, and L-Ido deoxynojirimycins are most effective in dually inhibiting GCS and GBA2. In contrast to our expectations, we found that the same holds true for the L-alt isomer. We believe that our comprehensive library, as reported here, could prove valuable in drug discovery endeavors targeting cancer, infectious diseases, and inherited glycosphingolipidoses.

Indexed as

1-DeoxynojirimycinEnzyme InhibitorsGlucosylceramidaseGlucosyltransferasesSmall Molecule LibrariesHumansIsomerismStereoisomerismStructure-Activity Relationship1-Deoxynojirimycinceramide glucosyltransferaseEnzyme InhibitorsGlucosylceramidaseGlucosyltransferasesSmall Molecule Libraries

Identifiers

PMID42679158
PMCPMC13528196

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.