ArticleProceedings of the National Academy of Sciences of the United States of America2026
A multispecies toolkit of
David Ontoso, Monika Mehta, Aidin Shabro, John Dittmar, Robert J D Reid, Rodney Rothstein, John L Nitiss, Scott Keeney
Abstract read
In one paragraphArticle in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
8 authors.
David OntosoMolecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Monika MehtaMolecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Aidin ShabroMolecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
John DittmarDepartment of Biological Sciences, Columbia University, New York, NY 10027.
Robert J D ReidDepartment of Genetics and Development (in Systems Biology), Columbia University Irving Medical Center, New York, NY 10032.
Rodney RothsteinDepartment of Genetics and Development (in Systems Biology), Columbia University Irving Medical Center, New York, NY 10032.
John L NitissPharmaceutical Sciences Department, Retzky College of Pharmacy, University of Illinois Chicago, Rockford, IL 61107.
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI FRANCESCA M GANY · 1985 to 2026
$347.4MMolecular Mechanisms Underlying Recombination at DNA Double-Strand Breaks and Stalled Replication ForksR35GM118180 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Rodney J. ROTHSTEIN · 2016 to 2026
$8.5MMechanism and regulation of meiotic recombinationR35GM118092 · NIGMS · SLOAN-KETTERING INST CAN RESEARCH · PI Scott Keeney · 2016 to 2026
$7.0MMechanism of meiotic recombination in yeastR01GM058673 · NIGMS · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI KEENEY, SCOTT · 1999 to 2015
$6.0MANTITOPOISOMERASE DRUG ACTION IN YEASTR01CA052814 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI NITISS, JOHN L · 1990 to 2014
$2.7MBiochemical determinants of genome instability induced by eukaryotic topoisomerase IIR03CA297372 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI JOHN L NITISS · 2025 to 2026
$160kHHS | NIH | National Cancer Institute (NCI) P30 CA08748HHS | NIH | National Cancer Institute (NCI) R03 CA297372HHS | NIH | National Institute of General Medical Sciences (NIGMS) R01 GM058673HHS | NIH | National Institute of General Medical Sciences (NIGMS) R35 GM118092HHS | NIH | National Institute of General Medical Sciences (NIGMS) R35 GM118180MSK Center for Metastasis Research NANCI NIH HHS P30 CA008748NCI NIH HHS R01 CA052814NCI NIH HHS R03 CA297372NIGMS NIH HHS R01 GM058673NIGMS NIH HHS R35 GM118092NIGMS NIH HHS R35 GM118180Starr Cancer Consortium (SCC) I12-0008
6 · The paper itselfAbstract
DNA topoisomerase II (TOP2) generates transient DNA double-strand breaks that are trapped as TOP2-DNA covalent complexes (TOP2cc) by antibiotic and chemotherapy drugs. Here, we characterize tools for study of cellular responses to TOP2cc, exploiting a
Indexed as
DNA DamageDNA Topoisomerases, Type IIPoly-ADP-Ribose Binding ProteinsSaccharomyces cerevisiae ProteinsAnimalsAntigens, NeoplasmDNA Breaks, Double-StrandedDNA RepairHumansMiceMutationSaccharomyces cerevisiaeTopoisomerase II InhibitorsAntigens, NeoplasmDNA Topoisomerases, Type IIPoly-ADP-Ribose Binding ProteinsSaccharomyces cerevisiae ProteinsTOP2A protein, humanTop2a protein, mouseTOP2B protein, humanTop2b protein, mouseTOP2 protein, S cerevisiaeTopoisomerase II InhibitorsDNA double-strand breakSaccharomyces cerevisiaeTopoisomerase II
Identifiers
PMID42679034
PMCPMC13552660
What OpenQuestion holds
Textmetadata
Read underepoch 390