Evidence map›Paper›PMID 42679032›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Rbp-Jκ controls NK cell late maturation and migration via chromatin landscape remodeling.

Hongyan Peng, Yao Yang, Yongjie Liu, Shuting Wu, Die Hu, Xiaoyu Deng, Lanlan Huang, Yana Li, Peiwen Xiong, Qinglan Yang and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Hongyan Peng *Pediatrics Research Institute of Hunan Province, The Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha 410007, China.
Yao Yang *Department of Pharmacology, College of Pharmacy and Laboratory Medicine Science, Army Medical University, Chongqing 400038, China.
Yongjie Liu *Pediatrics Research Institute of Hunan Province, The Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha 410007, China.
Shuting WuPediatrics Research Institute of Hunan Province, The Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha 410007, China.
Die HuDepartment of Pharmacology, College of Pharmacy and Laboratory Medicine Science, Army Medical University, Chongqing 400038, China.
Xiaoyu DengDepartment of Pharmacology, College of Pharmacy and Laboratory Medicine Science, Army Medical University, Chongqing 400038, China.ORCID 0009-0002-0100-6263
Lanlan HuangThe School of Pediatrics, Hengyang Medical School, University of South China (Hunan Children's Hospital), Changsha 410007, China.
Yana LiPediatrics Research Institute of Hunan Province, The Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha 410007, China.
Peiwen XiongPediatrics Research Institute of Hunan Province, The Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha 410007, China.
Qinglan YangPediatrics Research Institute of Hunan Province, The Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha 410007, China.
Songyang LiPediatrics Research Institute of Hunan Province, The Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha 410007, China.
Bowen GongDepartment of Pharmacology, College of Pharmacy and Laboratory Medicine Science, Army Medical University, Chongqing 400038, China.
Yabin ZhangDepartment of Pharmacology, College of Pharmacy and Laboratory Medicine Science, Army Medical University, Chongqing 400038, China.
Liang SongDepartment of Pharmacology, College of Pharmacy and Laboratory Medicine Science, Army Medical University, Chongqing 400038, China.
Fangjie WangState Key Laboratory of Trauma and Chemical Poisoning, Army Medical University, Chongqing 400038, China.
Jianhua YuDivision of Hematology and Oncology, Department of Medicine, School of Medicine, University of California, Irvine, CA 92697.
Zhenghui XiaoPediatrics Research Institute of Hunan Province, The Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha 410007, China.
Yafei DengPediatrics Research Institute of Hunan Province, The Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha 410007, China.
Zhaoyang ZhongDepartment of Oncology, Fuling Hospital of Traditional Chinese Medicine, Chongqing University of Chinese Medicine, Chongqing 408000, China.
Youcai DengDepartment of Pharmacology, College of Pharmacy and Laboratory Medicine Science, Army Medical University, Chongqing 400038, China.ORCID 0000-0001-5488-8576

Funding

Chongqing Science and Technology Commission of China CSTB2022NSCQ-MSX1491Chongqing Science and Technology Commission of China CSTB2023TIAD-STX007Chongqing Science and Technology Commission of China CSTB2024NSCQ-JQX0041Chongqing Science and Technology Commission of China cstc2021jcyj-jqX0006Guangdong Association of Clinical Trials (GACT)/ Chinese Thoracic Oncology Group (CTONG), Guangdong Provincial Key Lab of Translational Medicine in Lung Cancer CTONG-YC20210104HSTD | Natural Science Foundation of Hunan Province () 2023JJ40349HSTD | Natural Science Foundation of Hunan Province () 2023JJ40352MOST | National Natural Science Foundation of China (NSFC) 81874313MOST | National Natural Science Foundation of China (NSFC) 81900055MOST | National Natural Science Foundation of China (NSFC) 81922068MOST | National Natural Science Foundation of China (NSFC) 82273938MOST | National Natural Science Foundation of China (NSFC) 82304510MOST | National Natural Science Foundation of China (NSFC) 82304511MOST | National Natural Science Foundation of China (NSFC) 82473935scientific research project of the hunan provincial health commision 20254893scientific research project of the hunan provincial health commision B202302078452scientific research project of the hunan provincial health commision B202302078468
6 · The paper itself

Abstract

The transcriptional regulator Rbp-Jκ is a pivotal molecular switch in Notch signaling; however, its cell-intrinsic role in natural killer (NK) cell maturation and migration remains incompletely understood. Here, we demonstrate that NK cell-specific deletion of Rbp-Jκ (

Indexed as

Cell MovementChromatin Assembly and DisassemblyImmunoglobulin J Recombination Signal Sequence-Binding ProteinKiller Cells, NaturalAnimalsCell DifferentiationKruppel-Like Transcription FactorsMiceMice, Inbred C57BLImmunoglobulin J Recombination Signal Sequence-Binding ProteinKruppel-Like Transcription FactorsRbpj protein, mousechromatin remodelingKlf2natural killer cellsNK cell traffickingRbp-Jκ

Identifiers

PMID42679032
PMCPMC13552845

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.