Evidence map›Paper›PMID 42679014›Full record

ArticleScience signaling2026

ORAI Ca

Boris Lavanderos, Alfredo Sanchez-Solano, Wanchun Zhu, Pratish Thakore, Evan Yamasaki, Yilin Chen, Yumei Feng Earley, Mohamed Trebak, Scott Earley

Abstract read
In one paragraph

Article in Science signaling, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Boris LavanderosDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642, USA.ORCID 0000-0002-6827-7095
Alfredo Sanchez-SolanoDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642, USA.ORCID 0000-0002-8218-256X
Wanchun ZhuDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642, USA.ORCID 0000-0002-0313-2119
Pratish ThakoreDepartment of Pharmacology, University of Nevada, Reno, Reno, NV 89557, USA.ORCID 0000-0002-2086-5453
Evan YamasakiDepartment of Pharmacology, University of Nevada, Reno, Reno, NV 89557, USA.ORCID 0000-0001-9052-039X
Yilin ChenDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642, USA.ORCID 0009-0006-4456-6155
Yumei Feng EarleyDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642, USA.ORCID 0000-0002-4138-0105
Mohamed TrebakDepartment of Pharmacology and Chemical Biology and UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.ORCID 0000-0001-6759-864X
Scott EarleyDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642, USA.ORCID 0000-0001-9560-2941

Funding

TRP channels as fundamental sensors of the cerebral microcirculationR35HL155008 · NHLBI · UNIVERSITY OF ROCHESTER · PI Scott Earley · 2021 to 2026
$5.5M
Ca2+ Signaling Networks in Health and DiseaseR35HL150778 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TREBAK, MOHAMED · 2020 to 2025
$5.4M
Spatiotemporal Control of Cerebral Blood Flow by Purinergic Signaling NetworksRF1NS148111 · NINDS · UNIVERSITY OF ROCHESTER · PI Scott Earley · 2026 to 2026
$1.6M
ORAI Channels and Neurovascular Coupling: Effects of AgingR01AG097446 · NIA · UNIVERSITY OF ROCHESTER · PI Scott Earley · 2026 to 2026
$561k
NHLBI NIH HHS R35 HL150778NHLBI NIH HHS R35 HL155008NIA NIH HHS R01 AG097446NINDS NIH HHS RF1 NS148111
6 · The paper itself

Abstract

Neurovascular coupling (NVC), which is initiated by the brain's dense capillary network, matches blood flow to neuronal activity. We found that ORAI1 channels and their regulator STIM1, the main drivers of store-operated Ca

Indexed as

Calcium ChannelsCapillariesNeurovascular CouplingORAI1 ProteinStromal Interaction Molecule 1AnimalsArteriolesCalciumCalcium SignalingEndothelial CellsMiceMice, KnockoutCalciumCalcium ChannelsORAI1 ProteinOrai1 protein, mouseOrai3 protein, mouseStim1 protein, mouseStromal Interaction Molecule 1

Identifiers

PMID42679014
PMCPMC13674552

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.