ArticlePhotochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology2026
Acute impact of afamelanotide on UVR erythemal and melanogenic responses in healthy humans in vivo: an exploratory study.
Article in Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Afamelanotide, an analogue of α-melanocyte stimulating hormone, activates the melanocortin-1 receptor and has a range of protective properties as demonstrated largely in vitro. While afamelanotide is approved to treat a visible light-induced inflammatory dermatosis, erythropoetic protoporphyria, its acute effects in vivo are poorly characterised. We explored short-term effects of afamelanotide on the acute inflammatory response of UVR-induced erythema and on the melanogenic response, in healthy humans. Participants (n = 9, 5 M:4 F, 27-43y, phototypes II-III) had melanin density and skin lightness measured at six skin sites using spectrophotometry. A broadband UVB dose-series (7-80 mJ/cm
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