ArticleApplied biochemistry and biotechnology2026
Investigation of Antibacterial, Antioxidant, and Burn Wound Healing Effects of Green-Synthesized Silver Nanoparticles Using Alcoholic Extract of Peucedanum officinale.
Article in Applied biochemistry and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Burn wounds remain a significant clinical challenge due to delayed tissue regeneration and the high risk of microbial infections. Green-synthesized silver nanoparticles using medicinal plant extracts have emerged as promising candidates for wound management; however, the potential of Peucedanum officinale-mediated silver nanoparticles for burn wound healing has not been extensively investigated. In this study, silver nanoparticles were synthesized using an alcoholic extract of P. officinale seeds (Ag@POS NPs), and their physicochemical characteristics, antimicrobial, antioxidant, and wound healing properties were evaluated. The synthesis process was optimized based on silver nitrate concentration, reaction time, and temperature. The synthesized nanoparticles were characterized using XRD, FTIR, FESEM, TEM, and EDS analyses. The XRD results confirmed the crystalline structure of Ag nanoparticles, while FTIR analysis indicated the involvement of plant-derived functional groups in nanoparticle formation and stabilization. Morphological analysis revealed the formation of spherical nanoparticles with an average size of approximately 20-30 nm. The antimicrobial activity of Ag@POS NPs demonstrated effective inhibition and elimination of Gram-positive and Gram-negative bacterial strains as well as Candida albicans. Moreover, Ag@POS NPs exhibited significant antioxidant activity, achieving 91% DPPH radical inhibition at 800 µg/mL. In a rat burn wound model, topical application of Ag@POS NPs significantly enhanced wound closure compared with control groups, which was further supported by histopathological findings indicating improved tissue regeneration. Overall, the findings demonstrate that green-synthesized Ag@POS NPs possess multifunctional antibacterial, antioxidant, and wound-healing properties, highlighting their potential as a promising therapeutic nanomaterial for burn wound management.
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