Evidence map›Paper›PMID 42678601›Full record

ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2026

Genomic insights into an optrA-carrying plasmid associated with linezolid resistance in clinical Enterococcus faecalis isolates, Argentina.

Celia Marìa Schell, Gloria Magi, Serena Simoni, Francesca Romana Massacci, Elisa Albini, Gloria D'Achille, Claudia Paoletti, Filomena Carriera, Gianluca Morroni, Marina Mingoia and 8 more

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Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Celia Marìa SchellCentro Universitario de Estudios Microbiológicos y Parasitológicos (CUDEMyP), Centro UNLP asociado a Comisión de Investigaciones Científicas (CIC), Facultad de Ciencias Médicas-Universidad Nacional de La Plata, Buenos Aires, Argentina.
Gloria MagiDepartment of Biomedical Sciences and Public Health, Polytechnic University of Marche Medical School, Ancona, Italy.
Serena SimoniDepartment of Life and Environmental Sciences, Polytechnic University of Marche, Ancona, Italy.
Francesca Romana MassacciDepartment of Research and Development, Istituto Zooprofilattico Sperimentale dell'Umbria e delle Marche 'Togo Rosati', Perugia, Italy.
Elisa AlbiniDepartment of Research and Development, Istituto Zooprofilattico Sperimentale dell'Umbria e delle Marche 'Togo Rosati', Perugia, Italy.
Gloria D'AchilleDepartment of Biomedical Sciences and Public Health, Polytechnic University of Marche Medical School, Ancona, Italy.
Claudia PaolettiDepartment of Biomedical Sciences and Public Health, Polytechnic University of Marche Medical School, Ancona, Italy.
Filomena CarrieraDepartment of Biomedical Sciences and Public Health, Polytechnic University of Marche Medical School, Ancona, Italy.
Gianluca MorroniDepartment of Biomedical Sciences and Public Health, Polytechnic University of Marche Medical School, Ancona, Italy.
Marina MingoiaDepartment of Biomedical Sciences and Public Health, Polytechnic University of Marche Medical School, Ancona, Italy.
Yao ZhuState Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150069, China.
Wanjiang ZhangState Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150069, China.
Xiang-Dang DuInternational Joint Research Center of National Animal Immunology, Ministry of Education Key Laboratory for Animal Pathogens and Biosafety, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, 450046, China.
Henrike Krüger-HakerInstitute of Microbiology and Epizootics, Centre for Infection Medicine, School of Veterinary Medicine, Freie Universität Berlin, Berlin, 14163, Germany.
Stefan SchwarzInstitute of Microbiology and Epizootics, Centre for Infection Medicine, School of Veterinary Medicine, Freie Universität Berlin, Berlin, 14163, Germany.
Judith Celina BernsteinCentro Universitario de Estudios Microbiológicos y Parasitológicos (CUDEMyP), Centro UNLP asociado a Comisión de Investigaciones Científicas (CIC), Facultad de Ciencias Médicas-Universidad Nacional de La Plata, Buenos Aires, Argentina.
Eleonora GiovanettiDepartment of Life and Environmental Sciences, Polytechnic University of Marche, Ancona, Italy.
Andrea BrencianiDepartment of Biomedical Sciences and Public Health, Polytechnic University of Marche Medical School, Ancona, Italy. a.brenciani@staff.univpm.it.ORCID http://orcid.org/0000-0001-5191-3908

Funding

National Natural Science Foundation of China U23A20241
6 · The paper itself

Abstract

The spread of the transferable optrA gene poses an increasing threat to the clinical efficacy of oxazolidinones. Here, we characterized a novel optrA-carrying plasmid, pEfa-optrA-Arg, from a linezolid-resistant Enterococcus faecalis clinical isolate from Argentina. The 68,653-bp conjugative plasmid harbored optrA together with multiple antimicrobial resistance genes and showed high similarity to a plasmid previously identified in a bovine isolate from Switzerland. pEfa-optrA-Arg, or a closely related variant, was also detected in E. faecalis isolates from several Argentinian hospitals, highlighting the role of horizontal gene transfer in the spread of antimicrobial resistance across human and animal reservoirs within the One Health continuum.

Indexed as

Conjugative plasmidsEnterococcus faecalisoptrAOxazolidinone resistanceST314

Identifiers

PMID42678601

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.