ArticleCell biochemistry and biophysics2026
Redox Imbalance, Oxidative DNA Damage, and Mitochondrial Membrane Depolarization Induced by Pervari Honey in SH-SY5Y Neuroblastoma Cells.
Article in Cell biochemistry and biophysics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Neuroblastoma remains a challenging malignancy in which redox imbalance and mitochondrial dysfunction represent potential cellular vulnerabilities. This study investigated the redox-associated cytotoxic effects and mitochondrial responses of Pervari honey (PH), a region-specific natural product from Türkiye, in SH-SY5Y neuroblastoma cells. MTT-based viability was assessed in SH-SY5Y neuroblastoma cells and L929 fibroblasts, used as a non-cancerous control cell model, after 48 h of PH exposure. Redox status was evaluated by measuring intracellular reactive oxygen species (ROS), total antioxidant capacity (TAC), total oxidant status (TOS), oxidative stress index (OSI), glutathione (GSH), malondialdehyde (MDA), and 8-hydroxy-2'-deoxyguanosine (8-OHdG). Mitochondrial membrane potential (ΔΨm) was analyzed using the JC-10 assay. Expression levels of apoptosis- and antioxidant-related genes were determined by RT-qPCR. Comparative viability analysis showed that L929 fibroblasts were less affected by PH exposure than SH-SY5Y cells, and the IC50 value of PH was not reached in L929 cells within the tested concentration range. Treatment increased ROS production and shifted the oxidant/antioxidant balance toward oxidative stress, as indicated by increased TOS and OSI and decreased TAC and GSH levels. Elevated MDA and 8-OHdG levels confirmed oxidative damage to lipids and DNA. Additionally, PH reduced mitochondrial membrane potential and altered the expression of apoptosis- and antioxidant-related genes, including cytochrome c (Cyt-c), p53, SOD1, and CAT. PH exerted cytotoxic effects in SH-SY5Y cells through redox imbalance and mitochondrial dysfunction. These findings suggest that PH may influence redox-sensitive pathways in neuroblastoma cells. However, further studies including compositional analysis and appropriate controls are required to clarify the underlying mechanisms.
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