Evidence map›Paper›PMID 42678538›Full record

ArticleArchives of microbiology2026

Biocontrol potential of endophytic fungal-derived 3-Hydroxy-1,2-dimethyl-4 (1H)-pyridone against Venturia inaequalis.

Madeeha Naik, Zafir A Naik, Andleeb Amin, Gulzar A Rather, Suhail Ashraf, Syed Inam Ul Haq, Javeed Iqbal Ahmad Bhat, Zahoor A Bhat, Bhagyashree Dhekale, Sajad M Zargar and 2 more

Abstract read
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Article in Archives of microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Madeeha NaikTranscriptomics Laboratory (K-Lab), Division of Plant Biotechnology, Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir, Shalimar, Srinagar, J&K, 190025, India.
Zafir A NaikDivision of Genetics and Plant Breeding, Faculty of Agriculture, Wadura, Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir, Shalimar, Srinagar, J&K, India.
Andleeb AminTranscriptomics Laboratory (K-Lab), Division of Plant Biotechnology, Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir, Shalimar, Srinagar, J&K, 190025, India.
Gulzar A RatherTranscriptomics Laboratory (K-Lab), Division of Plant Biotechnology, Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir, Shalimar, Srinagar, J&K, 190025, India.
Suhail AshrafDepartment of Plant Biotechnology, Tamil Nadu Agricultural University Coimbatore, Coimbatore, 641003, India.
Syed Inam Ul HaqTranscriptomics Laboratory (K-Lab), Division of Plant Biotechnology, Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir, Shalimar, Srinagar, J&K, 190025, India.
Javeed Iqbal Ahmad BhatDivision of Basic Science and Humanities, Sher-E-Kashmir University of Agricultural Sciences and Technology of Kashmir, Shalimar, Srinagar, J&K, 190025, India.
Zahoor A BhatDivision of Plant Pathology, Sher-E-Kashmir University of Agricultural Sciences and Technology of Kashmir, Shalimar, Srinagar, J&K, 190025, India.
Bhagyashree DhekaleDivision of Agricultural Statistics, Sher-E-Kashmir University of Agricultural Sciences and Technology of Kashmir, Shalimar, Srinagar, J&K,, 190025, India.
Sajad M ZargarProteomics Lab, Division of Plant Biotechnology, Faculty of Horticulture, Sher-E-Kashmir University of Agricultural Sciences and Technology of Kashmir, Shalimar, Srinagar, J&K, 190025, India.
Alamgir A DarResearch Centre for Residue and Quality Analysis, Sher-E-Kashmir University of Agricultural Sciences and Technology of Kashmir, Shalimar, Srinagar, J&K, 190025, India.
Khalid Z MasoodiTranscriptomics Laboratory (K-Lab), Division of Plant Biotechnology, Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir, Shalimar, Srinagar, J&K, 190025, India. masoodikz@skuastkashmir.ac.in.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Apple scab, caused by the pathogenic fungus Venturia inaequalis, is one of the most devastating diseases affecting apple production worldwide. Scab is primarily controlled through frequent applications of chemical fungicides, which are costly and pose significant risks to human health and the environment. In this context, the present investigation aimed to explore the diversity of endophytic fungi associated with apple cultivars, their antimicrobial potential and organic bioactive compounds, which could be used as bio-control agents against scab. 51 isolates of endophytic fungi were extracted from scab-resistant and susceptible apple cultivars. Their morphological and molecular examination resulted in the identification of 26 fungal strains. In vitro antifungal examination of identified fungal strains against V. inaequalis confirmed antagonistic activity of Fusarium oxysporum and F. solani. Bioactive compound responsible for antagonistic activity was purified and structurally characterized as 3-Hydroxy-1,2-dimethyl-4(1H)-pyridone (HDMP). Molecular docking studies of HDMP revealed favorable binding affinities toward the fungal target proteins, CYP51 and succinate dehydrogenase. Additionally, on-field application of F. oxysporum showed promising results in controlling apple scab. Overall, present study identified the antagonistic fungal strains from the apple cultivars and the bioactive compound HDMP, offering a sustainable and eco-friendly approach to apple scab management.

Indexed as

Antifungal AgentsAscomycotaBiological Control AgentsEndophytesFungiMalusPlant DiseasesPyridonesAntibiosisFungal ProteinsFusariumMolecular Docking SimulationSuccinate DehydrogenaseAntifungal AgentsBiological Control AgentsFungal ProteinsPyridonesSuccinate Dehydrogenase3-Hydroxy-1,2-dimethyl-4(1H)-pyridoneBiocontrolEndophyteSecondary metabolitesVenturia inaequalis

Identifiers

PMID42678538

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.