Evidence map›Paper›PMID 42678495›Full record

ArticleJournal of physiology and biochemistry2026

Exercise elicits mitonuclear protein imbalance and UPR

Matheus Biscaro Rocha, Izabela Monteiro de Araujo, Saulo Gabriel do Nascimento Della Coleta, Scylas J A Junior, Sidney F Peres, Renata R Braga, Rafael S Brícola, Fernanda S Carneiro, Barbara M Crisol, Raul G da Costa and 5 more

Abstract read
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In one paragraph

Article in Journal of physiology and biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Matheus Biscaro Rocha *Laboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas (UNICAMP), Limeira, São Paulo, 13484-350, Brazil.
Izabela Monteiro de Araujo *Laboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas (UNICAMP), Limeira, São Paulo, 13484-350, Brazil.
Saulo Gabriel do Nascimento Della Coleta *Laboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas (UNICAMP), Limeira, São Paulo, 13484-350, Brazil.
Scylas J A JuniorLaboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas (UNICAMP), Limeira, São Paulo, 13484-350, Brazil.
Sidney F PeresLaboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas (UNICAMP), Limeira, São Paulo, 13484-350, Brazil.
Renata R BragaLaboratory of Nutritional Genomics, University of Campinas(UNICAMP), Limeira, São Paulo, Brazil.
Rafael S BrícolaLaboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas (UNICAMP), Limeira, São Paulo, 13484-350, Brazil.
Fernanda S CarneiroLaboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas (UNICAMP), Limeira, São Paulo, 13484-350, Brazil.
Barbara M CrisolSorbonne Université, Inserm, Centre de Recherche en Myologie, Paris, UMRS974, France.
Raul G da CostaDepartment of Biochemistry and Tissue Biology, University of Campinas, Campinas, Brazil.
Marcelo A S MoriDepartment of Biochemistry and Tissue Biology, University of Campinas, Campinas, Brazil.
Dennys E CintraLaboratory of Nutritional Genomics, University of Campinas(UNICAMP), Limeira, São Paulo, Brazil.
Adelino S R da SilvaPostgraduate Program in Rehabilitation and Functional Performance, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil.
José R PauliLaboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas (UNICAMP), Limeira, São Paulo, 13484-350, Brazil.
Eduardo Rochete RopelleLaboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Sciences, University of Campinas (UNICAMP), Limeira, São Paulo, 13484-350, Brazil. eropelle@unicamp.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitochondrial dysfunction plays a critical role in the development of metabolic dysfunction-associated steatotic liver disease (MASLD). It has been proposed that mitochondrial unfolded-protein response (UPR

Indexed as

LiverMitochondria, LiverMitochondrial ProteinsObesityPhysical Conditioning, AnimalUnfolded Protein ResponseAnimalsDiet, High-FatEndopeptidase ClpHumansMaleMiceMice, Inbred C57BLProteostasisCLPP protein, mouseEndopeptidase ClpMitochondrial ProteinsExercise; Mitonuclear protein imbalance; UPRmt; MASLD; Obesity; Liver; Mitochondrial proteostasis

Identifiers

PMID42678495
PMCPMC13534197

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.