ReviewCurrent pain and headache reports2026
The Sinuvertebral Nerve and Basivertebral Nerve: Analyzing the Central Role of the Vertebral-Disc Unit in Chronic Low Back Pain.
Review in Current pain and headache reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewLow back pain (LBP) is a leading cause of disability worldwide, and its chronic forms-discogenic low back pain (DLBP) and vertebrogenic low back pain (VLBP)-remain difficult to diagnose and treat precisely. This review aims to clarify the anatomical and neurophysiological roles of the sinuvertebral nerve (SVN) and basivertebral nerve (BVN) in chronic LBP and to examine their implications for targeted diagnosis and treatment. RECENT
findingsRecent advances in neuroanatomy and imaging have shown that the SVN primarily mediates pain from intervertebral disc pathology, whereas the BVN is closely associated with vertebral endplate and marrow changes, particularly Modic changes. These two nerves are anatomically and functionally linked and together form a "vertebral-disc sensory unit." Emerging evidence supports nerve-targeted interventions, including sinuvertebral and basivertebral nerve radiofrequency ablation, which can improve pain relief and functional outcomes in carefully selected patients. Functional and molecular imaging techniques are also expanding the ability to identify pain-generating structures more precisely. The SVN and BVN are key neural pathways in the pathogenesis of chronic LBP and represent important targets for precision diagnosis and treatment. Recognizing the vertebral-disc sensory unit provides a more integrated understanding of DLBP and VLBP. A better anatomical, functional, and imaging-based characterization of these nerves may improve patient selection and clinical outcomes for nerve-targeted therapies.
Indexed as
Identifiers
42678490What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.