ArticleVirchows Archiv : an international journal of pathology2026
Evaluation of grading systems among pulmonary adenocarcinomas: architectural grade combined with STAS is superior to others - a single centre study.
Article in Virchows Archiv : an international journal of pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several grading methods had been proposed for pulmonary adenocarcinomas in the past decades. We aimed to evaluate and compare the prognostic performance of these grading schemes on overall survival (OS) and recurrence-free survival (RFS) in a single center study. Our retrospective study included patients diagnosed with lung adenocarcinoma who underwent surgery between 2010 and 2016 at the clinic of Szeged. Morphological patterns were recorded and revised on histological slides. As statistical analyses, Cox proportional hazard models, Kaplan-Meier analyses, log rank test and ROC analyses were applied. Altogether 304 patients were included in our study. In multivariate analysis of OS, type of surgery (HR:1.81, 95%CI:1.08-3.02, p = 0.025), architectural grade combined with spread through air spaces (STAS) (HR:4.38, 95%CI:1.88-10.20, p < 0.001), lymphovascular (HR:1.87, 95%CI:1.13-3.09, p = 0.014), and vascular spread (HR:2.07, 95%CI:1.00-4.25, p = 0.049) were independent prognostic factors. In multivariate analysis of RFS, stage (HR:2.84, 95%CI:1.42-5.67, p = 0.003) architectural grade combined with STAS (HR:3.13, 95%CI:1.70-5.32, p < 0.010) and vascular spread (HR:2.42, 95%CI:1.31-4.48, p = 0.005) proved to be independent prognosticators. In a subgroup analysis excluding the adverse factors the architectural grade combined with STAS preserved its prognostic impact on OS and RFS. Most grading systems of pulmonary adenocarcinoma take into consideration the architectural features; however, some of them focus on nuclear features or STAS. We have compared the available grading systems and have proven that almost all of them have prognostic role on survival. The architectural grade combined with STAS was superior to others even in subgroup analysis where adverse factors were omitted.
Indexed as
Identifiers
42678418What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.