EWSR1::ATF7 fusion driven mesenchymal neoplasm with rhabdomyoblastic differentiation.

Azfar Neyaz, Catherine K Gestrich, Aric Berning, Mohamed M Elmoryah, Lauren Zeitlinger, Ivy John

Abstract read

In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Azfar NeyazDepartment of Pathology, University of Pittsburgh, Pittsburgh, PA, USA. neyaza@upmc.edu.ORCID http://orcid.org/0000-0001-5321-190X

Catherine K GestrichDivision of Pediatric Pathology, University of Pittsburgh, Pittsburgh, PA, USA.

Aric BerningDepartment of Radiology, University of Pittsburgh, Pittsburgh, PA, USA.

Mohamed M ElmoryahDepartment of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.

Lauren ZeitlingerDepartment of Orthopedic Surgery, University of Pittsburgh, Pittsburgh, PA, USA.

Ivy JohnDepartment of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report a case of a 28-year-old man who presented with a slowly enlarging intramuscular mass in left posterior neck. Imaging demonstrated a relatively well-circumscribed mass with focal scattered calcifications. Histologic examination revealed a lobulated neoplasm composed of monotonous round to ovoid to spindle shaped tumor cells arranged in large nodules, loose fascicles, and solid nests within a sclerotic fibrous stromal background. Focal metaplastic bone formation and rare calcification were identified. No significant cytologic atypia, increased mitotic activity or necrosis was identified. The tumor showed immunophenotypic evidence of rhabdomyoblastic differentiation. Molecular studies identified a novel EWSR1::ATF7 fusion and methylation profiling yielded no matching classes. Overall, the findings favor classification as a fusion-associated spindle cell rhabdomyosarcoma. However, additional studies involving a larger number of cases will be required to confirm its classification as such and to better define its biologic behavior.

Indexed as

EWSR1::ATF7Fusion associated spindle cell rhabdomyosarcomaRhabdomyoblastic differentiation

Identifiers

PMID42678416

DOI10.1016/j.modpat.2026.101014

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.