ArticleOxidative medicine and cellular longevity2026
Experimental and In Silico Evaluation of Honey-Derived Phenolic Compounds: Antioxidant Activity, Anti-Inflammatory Potential Pharmacokinetic Properties, Toxicity Assessment, and Multitarget Anti-Inflammatory Potential.
Article in Oxidative medicine and cellular longevity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Experimental and In Silico Evaluation of Honey-Derived Phenolic Compounds: Antioxidant Activity, Anti-Inflammatory Potential Pharmacokinetic Properties, Toxicity Assessment, and Multitarget Anti-Inflammatory Potential.Oxidative medicine and cellular longevity · 2026Article
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6 authors.
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Abstract
Honey is a natural product rich in phenolic compounds that contribute to its antioxidant and anti-inflammatory properties. The present study aimed to evaluate the biological activities of honey samples collected from different regions of Kazakhstan through experimental assays and computational analyses of major honey-derived phenolic compounds. Ethanolic extracts of seven honey samples were prepared and assessed for extraction yield, total phenolic content, total flavonoid content (TFC), antioxidant activity using the DPPH radical scavenging assay, and anti-inflammatory activity using the albumin denaturation inhibition assay. In addition, five representative honey-derived phenolic compounds, namely fumaric acid, p-hydroxybenzoic acid, p-coumaric acid, trans-2-hydroxycinnamic acid, and chrysin, were subjected to comprehensive in silico analyses including ADME prediction, drug-likeness evaluation, toxicity assessment, and multitarget molecular docking. Extraction yields ranged from 6.8% to 8.7%. The highest total phenolic content was observed in sample B12 (80.1 ± 9.7 mg GAE/g extract), whereas the highest TFC was detected in sample B10 (6.8 ± 0.5 mg quercetin equivalent (QE)/g extract). DPPH radical scavenging activity revealed IC
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