ArticleJournal of virology2026
Conserved gammaherpesvirus protein kinase counters myeloid cell-specific type I IFN receptor but not IRF-3 expression to promote the establishment of chronic latent infection in the spleen.
Erika R Johansen, Matthew A Brown, Xander G Bradeen, Cade R Rahlf, Daniela Avila, Damon L Schmalzriedt, Vera L Tarakanova
Abstract read
In one paragraphArticle in Journal of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
7 authors.
Erika R Johansen *Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Matthew A Brown *Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.ORCID 0009-0003-0617-6904 Xander G BradeenDepartment of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Cade R RahlfDepartment of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Daniela AvilaDepartment of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Damon L SchmalzriedtDepartment of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Vera L TarakanovaDepartment of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.ORCID 0000-0002-9499-088X Funding
Gammaherpesvirus protein kinase: a master manipulator of the host during chronic infection.R01AI165578 · NIAID · MEDICAL COLLEGE OF WISCONSIN · PI Vera L. Tarakanova · 2022 to 2026
$2.3MFrom friend to foe: proviral role of IRF-3 in chronic gammaherpesvirus infectionR21AI182596 · NIAID · MEDICAL COLLEGE OF WISCONSIN · PI TARAKANOVA, VERA L. · 2024 to 2025
$440kUncovering the proviral role of B cell-intrinsic STAT1 expression during chronic gammaherpesvirus infectionF31AI191670 · NIAID · MEDICAL COLLEGE OF WISCONSIN · PI Erika R Johansen · 2025 to 2026
$100kDefining the proviral role of DnaJA1 in immune regulation and gammaherpesvirus infectionF31AI194704 · NIAID · MEDICAL COLLEGE OF WISCONSIN · PI Cade Rahlf · 2026 to 2026
$50kNational Institute of Allergy and Infectious Diseases AI165578, AI182596National Institute of Allergy and Infectious Diseases AI191670National Institute of Allergy and Infectious Diseases AI194704NIAID NIH HHS F31 AI191670NIAID NIH HHS F31 AI194704NIAID NIH HHS R01 AI165578NIAID NIH HHS R21 AI182596
6 · The paper itselfAbstract
Gammaherpesviruses are prevalent pathogens that are associated with cancers and autoimmune diseases. All gammaherpesviruses encode a conserved protein kinase. Expression of orf36, the protein kinase encoded by murine gammaherpesvirus 68 (MHV68), supports the establishment of a latent viral reservoir in splenic B cells
Indexed as
GammaherpesvirinaeHerpesviridae InfectionsInterferon Regulatory Factor-3Latent InfectionMyeloid CellsPersistent InfectionReceptor, Interferon alpha-betaRhadinovirusSpleenViral ProteinsVirus LatencyAnimalsB-LymphocytesInterferon Type IMiceMice, Inbred C57BLIfnar1 protein, mouseInterferon Regulatory Factor-3Interferon Type IIrf3 protein, mouseReceptor, Interferon alpha-betaSTAT1 Transcription FactorViral Proteinschronic infectiongammaherpesvirus protein kinaseIRF-3type I interferon
Identifiers
PMID42678291
PMCPMC13595937
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