ArticleInvestigative ophthalmology & visual science2026
OCT Biomarker Testing for Early Dysregulated Photoreceptor Metabolism in Dark-Reared Pde6brd10 Mice.
Article in Investigative ophthalmology & visual science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Purpose: The purpose of this study was to noninvasively test the hypothesis that dysregulated photoreceptor metabolism occurs with early retinal degeneration in dark-reared Pde6brd10 mice. Methods: Postnatal day 23 (P23) phosphodiesterase (PDE) mutant (Pde6brd10) mice, P23 wild-type (WT) mice were continuously dark-reared, and 2-month-old dark-adapted (DA) C57BL/6J WT mice were studied following acute injection of the carbonic anhydrase inhibitor acetazolamide (ACZ) or saline control. Two optical coherence tomography (OCT) metabolic biomarkers were measured: (i) external limiting membrane-retinal pigment epithelium (ELM-RPE) thickness, a proxy for subretinal space acidosis, and (ii) the profile shape aspect ratio of the hyper-reflective band just distal to the ELM (band 2), a proxy for mitochondrial configuration within photoreceptor inner segments. Retinal laminar thicknesses were also assessed. Results: P23 Pde6brd10 mice responded to ACZ with ELM-RPE contraction, but no change in band 2 profile shape aspect ratio; outer nuclear layer thickness was subnormal. In contrast, P23 WT mice showed no change in either OCT metabolic biomarker following ACZ administration. DA 2-month-old WT mice showed ELM-RPE contraction with ACZ; band 2 profile shape aspect ratio increased in male mice, with no change in female mice. Conclusions: P23 Pde6brd10 mice with limited rod atrophy had biomarker values suggestive of dysregulation of RPE fluid/ion transport but with stable rod mitochondrial configuration following ACZ. DA 2-month-old male WT mice biomarkers were responsive to ACZ in a manner similar to those in light-adapted 2-month-old male WT mice; the difference in biomarker response pattern in female WT mice suggests a possible hormonal influence.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.