ArticleTurkish journal of pharmaceutical sciences2026
Development of Mucoadhesive Nanofiber as an Alternate Therapeutic Regimen for Subclinical Endometritis in Cattle.
Article in Turkish journal of pharmaceutical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: Subclinical endometritis in cattle is still a problem that has a detrimental effect on dairy production and fertility. Traditional intrauterine or systemic antibiotic treatments frequently result in suboptimal uterine drug levels, encourage resistance, and increase the possibility of drug residues in food items. The current study aimed to treat subclinical endometritis in repeat breeders by creating and testing an ofloxacin (Ofx)-loaded mucoadhesive polyvinyl alcohol/chitosan nanofiber using the electrospinning technique. Materials and Methods: The process constants were optimised using a central composite design to create a uniform nanofiber with maximum mechanical properties. Furthermore, Results: The scanning electron microscopy image of Ofx nanofiber suggests a diameter of 190-210 nm and tensile strength of 1.33 tensile strength with an entrapment efficiency of 97.54 ± 0.89%. Ofx delivered via nanofiber exhibited sustained release of Ofx up to 216 hours. Ex vivo assessments demonstrated stronger adherence and higher retention, while Conclusion: Ofx-loaded nanofibers offer a novel and promising localized and mucoadhesive drug delivery approach for subclinical endometritis in cattle. Future research must prioritise further
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