Evidence map›Paper›PMID 42678149›Full record

Trial reportMicrobiology spectrum2026

Vaginal microbe-binding antibody interactions with a

Rachel Liu, Eric Armstrong, Anke Hemmerling, Steve Miller, Sanja Huibner, Laurel Lagenaur, Thomas P Parks, Craig R Cohen, Bryan Coburn, Rupert Kaul

Registry-linked trialAbstract readClinical Trial, Phase IIMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02766023 (Phase II-b Randomized Double-Blind Placebo-Controlled Trial of Lactobacillus Crispatus CTV-05), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02766023 phase2completednot on this map

Phase II-b Randomized Double-Blind Placebo-Controlled Trial of Lactobacillus Crispatus CTV-05 (LACTIN-V) to Prevent the Recurrence of Bacterial Vaginosis

TypeinterventionalSponsorNational Institute of Allergy and Infectious Diseases (NIAID)Ran2016 to 2019Enrolled228ConditionsBacterial VaginosisArmsLactobacillus crispatus CTV-05, Metronidazole, Placebo
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rachel LiuDepartment of Medicine, University of Toronto, Toronto, Canada.
Eric ArmstrongToronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada.ORCID 0000-0002-4530-6631
Anke HemmerlingDepartment of Obstetrics, Gynecology & Reproductive Sciences, University of California, San Francisco, San Francisco, California, USA.
Steve MillerDepartment of Laboratory Medicine, University of California, San Francisco, San Francisco, California, USA.ORCID 0000-0002-9188-3392
Sanja HuibnerDepartment of Medicine, University of Toronto, Toronto, Canada.
Laurel LagenaurOsel, Mountain View, California, USA.
Thomas P ParksOsel, Mountain View, California, USA.ORCID 0000-0002-0251-0229
Craig R CohenDepartment of Obstetrics, Gynecology & Reproductive Sciences, University of California, San Francisco, San Francisco, California, USA.
Bryan CoburnDepartment of Medicine, University of Toronto, Toronto, Canada.ORCID 0000-0003-0150-4510
Rupert KaulDepartment of Medicine, University of Toronto, Toronto, Canada.ORCID 0000-0002-1586-4093

Funding

CIHR PJT-156123CIHR PJT-180629NIH HHS HHSN27200007NIH HHS HHSN2722013000141
6 · The paper itself

Abstract

The vaginal application of LACTIN-V, a live biotherapeutic containing IMPORTANCE: Recent clinical trials show that vaginal live biotherapeutics (therapeutic grade probiotics) containing the "optimal" vaginal species CLINICAL TRIALS: This study is registered with ClinicalTrials.gov as NCT02766023.

Indexed as

Antibodies, BacterialLactobacillus crispatusProbioticsVaginaVaginosis, BacterialAdministration, IntravaginalAdultFemaleHumansImmunoglobulin AImmunoglobulin GMetronidazoleYoung AdultAntibodies, BacterialImmunoglobulin AImmunoglobulin GMetronidazolebacterial vaginosisfemale genital tractlive biotherapeuticmucosal antibodiesmucosal immunityreproductive health

Identifiers

PMID42678149
PMCPMC13689376

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.