Evidence map›Paper›PMID 42678063›Full record

ReviewGut microbes2026

Unraveling the drug resistance web in IBD: The gut microbiota-immunity-epigenetics axis.

Qing Li, Mingrong Cheng, Xiaoyue Wang, Weiwei Li, Feng Zhang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Gut microbes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Qing LiDepartment of General Practice, Minhang District Pujin Community Health Service Center, Shanghai, China.
Mingrong ChengDepartment of General Surgery, Nanxiang Branch of Ruijin Hospital, Shanghai, China.ORCID 0000-0002-2891-407X
Xiaoyue WangDepartment of General Practice, Minhang District Pujin Community Health Service Center, Shanghai, China.
Weiwei LiDepartment of General Practice, Minhang District Pujin Community Health Service Center, Shanghai, China.
Feng ZhangDepartment of General Practice, Minhang District Pujin Community Health Service Center, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Drug resistance in inflammatory bowel disease (IBD) precision therapy remains a critical barrier to clinical outcomes, with traditional studies focusing on single molecules or isolated pathways but failing to systematically dissect the bidirectional, context-dependent dynamic crosstalk among gut microbiota, immunity, and epigenetic modifications. This review dissects resistance mechanisms of key biologics (e.g., antitumor necrosis factor-

Indexed as

Drug ResistanceEpigenesis, GeneticGastrointestinal MicrobiomeInflammatory Bowel DiseasesAnimalsDysbiosisHumansbiomarkersdrug resistancegut microbiota-immunity-epigenetics axisInflammatory bowel diseaseprecision interventiontriple-loop hierarchical regulation model

Identifiers

PMID42678063
PMCPMC13540173

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.