ArticleAmerican journal of physiology. Endocrinology and metabolism2026
Adipocyte β3-adrenergic receptor signaling attenuates leptin production but is dispensable for fasting induced leptin suppression.
Samuel R Heaselgrave, Steven C Wyler, Shreya Thomas, Arely Tinajero, Marco Galvan, Emma Mihaila, Roger Fan, Teppei Fujikawa, Philipp E Scherer, Joel K Elmquist
Abstract read
In one paragraphArticle in American journal of physiology. Endocrinology and metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
10 authors.
Samuel R HeaselgraveCenter for Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, United States.ORCID 0009-0001-1749-9229 Steven C WylerCenter for Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, United States.
Shreya ThomasCenter for Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, United States.
Arely TinajeroCenter for Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, United States.
Marco GalvanCenter for Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, United States.
Emma MihailaCenter for Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, United States.
Roger FanCenter for Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, United States.
Teppei FujikawaCenter for Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, United States.
Philipp E SchererTouchstone Diabetes Center, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, United States.ORCID 0000-0003-0680-3392 Joel K ElmquistCenter for Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, United States.ORCID 0000-0001-6929-6370 Funding
Metabolic Benefits of Leptin ReductionR01DK127274 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI JOEL K. ELMQUIST, PHILIPP E SCHERER · 2021 to 2026
$5.1MSF1 neurons and sympathetic regulation of glucose homeostasisR01DK100659 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI JOEL K. ELMQUIST · 2014 to 2026
$4.8MInteractions of Leptin and the Melanocortin SystemR01DK118725 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI JOEL K. ELMQUIST · 2018 to 2026
$3.5MNEUROANATOMIC MECHANIMS OF LEPTIN ACTIONR01DK053301 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI ELMQUIST, JOEL K · 1998 to 2006
$3.0MRegulation of obesity-related inflammation by alpha-melanocyte stimulating hormoneR01DK142982 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI JOEL K. ELMQUIST, sarah huen · 2026 to 2026
$813kHHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) 2R01DK100659HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) 2R01DK118725HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) 2R01DK127274NIDDK NIH HHS R01 DK053301NIDDK NIH HHS R01 DK100659NIDDK NIH HHS R01 DK118725NIDDK NIH HHS R01 DK127274NIDDK NIH HHS R01 DK142982
6 · The paper itselfAbstract
Leptin, secreted by adipocytes, conveys the status of peripheral energy stores to the brain to regulate appetite and metabolism. Although sympathetic activation via β3-adrenergic receptors (β3-ARs) has been shown to suppress leptin expression, it remains unclear whether this regulation arises directly within adipocytes or through other populations. In addition, it is unclear whether β3-AR signaling contributes to the fasting-induced reduction in leptin. To address this, we generated a novel
Indexed as
AdipocytesFastingLeptinReceptors, Adrenergic, beta-3Adipose Tissue, WhiteAnimalsMaleMiceMice, Inbred C57BLMice, TransgenicSignal TransductionAdrb3 protein, mouseLeptinReceptors, Adrenergic, beta-3adipocyteleptinsympathetic signalingβ3-adrenergic receptor
Identifiers
PMID42678047
PMCPMC13622890
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