ArticleJournal of cell science2026
Beadex modulates haematopoiesis and innate immune defence against microbial infection in Drosophila melanogaster.
Article in Journal of cell science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
LIM domain-only (LMO) proteins are associated with chromosomal translocations in T-cell acute lymphoblastic leukaemia and are highly expressed in acute myeloid leukaemia, correlating with poor prognosis. However, their role in myeloid cell lineage specification and function remains poorly understood. Using Drosophila melanogaster, which has a single LMO protein homologue, Beadex (Bx or dLMO), and a conserved myeloid-like immune system, we investigated the in vivo role of Beadex in plasmatocytes, the macrophage-like blood cells of Drosophila. Loss of Beadex reduced lymph gland size and the area of mature plasmatocytes. RNA sequencing of Beadex knockdown haemocytes revealed transcriptional changes affecting actin cytoskeleton regulation, phagosome formation and immune response pathways. Accordingly, Beadex mutant and knockdown haemocytes exhibited reduced phagocytic index and lamellipodium area. Beadex regulates actin remodelling through transcriptional control of profilin (chickadee or chic), and profilin overexpression restored the phagocytic index to control levels. Haemocyte-specific Beadex overexpression increased susceptibility to Salmonella infection, which was associated with elevated eiger (TNF) signalling and immunopathology independent of bacterial burden. Overall, Beadex coordinates myeloid cell development, cytoskeletal dynamics and immune defence, with conserved parallels in vertebrate LMO2 biology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.