Evidence map›Paper›PMID 42677730›Full record

Trial reportDiabetes, obesity & metabolism2026

Dietary Soybean vs. Palm Oils Differ in Effects on Liver Fat in Adults With MAFLD: A 16-Week, Double-Masked, Randomized Controlled Trial.

Martha A Belury, Rachel M Cole, Ai Ni, Arunark Kolipaka, Manjunathan Nanjappa, Kristin Thompson, Ali Kalhori, Stephan Zarich, Rolando E Choriego, Rafael Jimenez-Flores and 1 more

Registry-linked trialAbstract readRandomized Controlled TrialComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Diabetes, obesity & metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05199948 (Weight, Energy, Lipids, and the Liver), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05199948 naactive not recruitingnot on this map

Weight, Energy, Lipids, and the Liver (WELL) Study: Dietary Fat Quality and Ectopic Lipids in the Liver

TypeinterventionalSponsorOhio State UniversityRan2022 to 2026Enrolled74ConditionsNonalcoholic Fatty LiverArmsSoybean Oil Foods, Palm Oil Foods
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Martha A BeluryDepartment of Food Science and Technology, The Ohio State University, Columbus, Ohio, USA.ORCID https://orcid.org/0000-0002-6480-4281
Rachel M ColeDepartment of Food Science and Technology, The Ohio State University, Columbus, Ohio, USA.
Ai NiDivision of Biostatistics, The Ohio State University, Columbus, Ohio, USA.
Arunark KolipakaDepartment of Radiology, The Ohio State University, Columbus, Ohio, USA.
Manjunathan NanjappaDepartment of Radiology, The Ohio State University, Columbus, Ohio, USA.
Kristin ThompsonDepartment of Radiology, The Ohio State University, Columbus, Ohio, USA.
Ali KalhoriDepartment of Food Science and Technology, The Ohio State University, Columbus, Ohio, USA.
Stephan ZarichDepartment of Food Science and Technology, The Ohio State University, Columbus, Ohio, USA.
Rolando E ChoriegoDepartment of Food Science and Technology, The Ohio State University, Columbus, Ohio, USA.
Rafael Jimenez-FloresDepartment of Food Science and Technology, The Ohio State University, Columbus, Ohio, USA.
Na LiDivision of Gastroenterology Hepatology and Nutrition, The Ohio State University, Columbus, Ohio, USA.

Funding

The OSU Center for Clinical and Translational Science: Advancing Today's Discoveries to Improve HealthUM1TR004548 · NCATS · OHIO STATE UNIVERSITY · PI CYNTHIA A GERHARDT, JULIE A. JOHNSON · 2023 to 2026
$22.0M
NCATS NIH HHS Grant 336 UM1TR004548NCATS NIH HHS UM1 TR004548Ohio Agriculture Research and Development Center, Wooster, OhioUnited Soybean Board (2411-108-0101), Soy Nutrition Institute Global
6 · The paper itself

Abstract

backgroundDietary linoleic acid (LA)-rich oils reduce liver fat in healthy adults who are not otherwise undergoing weight loss strategies. Effects on the liver fat in adults with fatty liver disease are unknown.

objectiveThe objective of this randomized double-masked controlled trial was to compare the effects of a dietary soybean oil (SO) which is high in LA vs. palm oil (PO) which is composed of a mixture of saturated, mono- and polyunsaturated fats, on changes of liver fat level in adults with MAFLD.

methodsAdults with MAFLD were recruited to complete a double-masked, randomized controlled trial consisting of a 2-week run-in period followed by a 16-week dietary intervention. Study foods contained either SO or PO to deliver 30 g oils per day. At week 0 and week 16, liver fat and visceral adipose tissue were measured by

resultsSixty-five adults with MAFLD (mean age ~53 y, BMI 36 kg/m

conclusionsThere was no significant difference for the effect of PO over SO on liver fat change when controlling for baseline liver fat or weight change. Larger trials testing dietary strategies that reduce liver fat in adults with MAFLD in the context of weight change are needed. TRAIL REGISTRATION: The WELL study is registered on ClinicalTrials.gov (NCT05199948).

Indexed as

LiverNon-alcoholic Fatty Liver DiseasePalm OilSoybean OilAdultDouble-Blind MethodFemaleHumansIntra-Abdominal FatMaleMiddle AgedPalm OilSoybean Oilcardiometabolic diseaseGLP‐1 receptor agonistshepatic fatlinoleic acidliver fatnon‐alcoholic fatty liver diseasepalm oilpolyunsaturated fatty acidssoybean oilvisceral adipose tissue

Identifiers

PMID42677730
PMCPMC13646368

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.