Evidence map›Paper›PMID 42677608›Full record

ArticleJournal of agricultural and food chemistry2026

Peptidomic Characterization and Functional Properties of Goat and Cow Milk Kefir before and after In Vitro Digestion.

Rayssa Cruz Lima, Bum Jin Kim, Carini Aparecida Lelis, Brianne Wai, Rohit Kumar, Jelmir Craveiro de Andrade, Marie Biondi Ryan, David C Dallas, Carlos Adam Conte-Junior

Abstract read
In one paragraph

Article in Journal of agricultural and food chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rayssa Cruz LimaGraduate Program in Veterinary Hygiene (PPGHV), Faculty of Veterinary Medicine, Fluminense Federal University (UFF), Vital Brazil Filho, Niterói, Rio de Janeiro24230-340, Brazil.ORCID 0000-0003-1428-0413
Bum Jin KimNutrition Program, School of Nutrition and Public Health, College of Health, Oregon State University, Corvallis, Oregon97331, United States.ORCID 0000-0001-9747-4111
Carini Aparecida LelisCenter for Food Analysis (NAL), Department of Biochemistry (DBq), Chemistry Institute, Federal University of Rio de Janeiro (UFRJ), Cidade Universitária, Rio de Janeiro, Rio de Janeiro21941-598, Brazil.
Brianne WaiNutrition Program, School of Nutrition and Public Health, College of Health, Oregon State University, Corvallis, Oregon97331, United States.
Rohit KumarNutrition Program, School of Nutrition and Public Health, College of Health, Oregon State University, Corvallis, Oregon97331, United States.
Jelmir Craveiro de AndradeCenter for Food Analysis (NAL), Department of Biochemistry (DBq), Chemistry Institute, Federal University of Rio de Janeiro (UFRJ), Cidade Universitária, Rio de Janeiro, Rio de Janeiro21941-598, Brazil.ORCID 0000-0002-4886-302X
Marie Biondi RyanNutrition Program, School of Nutrition and Public Health, College of Health, Oregon State University, Corvallis, Oregon97331, United States.ORCID 0000-0003-4415-184X
David C DallasNutrition Program, School of Nutrition and Public Health, College of Health, Oregon State University, Corvallis, Oregon97331, United States.ORCID 0000-0002-9696-0967
Carlos Adam Conte-JuniorGraduate Program in Veterinary Hygiene (PPGHV), Faculty of Veterinary Medicine, Fluminense Federal University (UFF), Vital Brazil Filho, Niterói, Rio de Janeiro24230-340, Brazil.ORCID 0000-0001-6133-5080

Funding

Orbitrap Elite with ETDS10OD020111 · OD · OREGON STATE UNIVERSITY · PI MAIER, CLAUDIA S · 2015 to 2015
$600k
Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico 140873/2021-0Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico 200468/2022-7Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico 313119/2020-1Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico 402215/2022-2Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior 001Funda??o Carlos Chagas Filho de Amparo ? i Pesquisa do Estado do Rio de Janeiro E-26/200.265/2024Funda??o Carlos Chagas Filho de Amparo ? i Pesquisa do Estado do Rio de Janeiro E-26/200.891/2021Funda??o Carlos Chagas Filho de Amparo ? i Pesquisa do Estado do Rio de Janeiro E-26.202.069/2025Funda??o Carlos Chagas Filho de Amparo ? i Pesquisa do Estado do Rio de Janeiro E-26.202.431/2026Funda??o Carlos Chagas Filho de Amparo ? i Pesquisa do Estado do Rio de Janeiro E-26/210.095/2023Funda??o Carlos Chagas Filho de Amparo ? i Pesquisa do Estado do Rio de Janeiro E-26/210.142/2023Funda??o Carlos Chagas Filho de Amparo ? i Pesquisa do Estado do Rio de Janeiro E-26.210.505/2025NIH HHS S10 OD020111NIH Office of the Director 1S10OD020111-01
6 · The paper itself

Abstract

Kefir is a fermented beverage produced from goat or cow milk. This study evaluated the bioactive potential and peptidomic profile of kefirs from both species before and after in vitro digestion. Peptides from undigested, gastric, and intestinal phases were characterized by LC-MS/MS. In silico tools identified sequences homologous to known bioactive peptides, with functions such as antihypertensive, immunomodulatory, and anticancer. β-casein was identified as the main precursor protein, with the highest number of peptides identified during the gastric phase. Undigested kefir showed antioxidant activity in ABTS and FRAP assays, and peptide extracts from both kefirs exhibited activity in all antioxidant assays across digestion phases. Antimicrobial activity against E. coli and S. aureus was observed before digestion for both kefir peptides; however, after digestion, only goat kefir peptides remained active against E. coli. This data indicates that kefir peptides are promising bioactive compounds for food and pharmaceutical applications.

Indexed as

KefirMilkPeptidesAmino Acid SequenceAnimalsAnti-Bacterial AgentsAntioxidantsBioactive Peptides, DietaryCattleDigestionEscherichia coliGoatsStaphylococcus aureusTandem Mass SpectrometryAnti-Bacterial AgentsAntioxidantsBioactive Peptides, DietaryPeptidesangiotensin-converting enzyme inhibitorybovine milkcaprine milkdairyfree-radical scavengingmass spectrometrymicrobial processing

Identifiers

PMID42677608
PMCPMC13523750

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.