Evidence map›Paper›PMID 42677492›Full record

Observational studyCirculation2026

Noninvasive Thrombus Imaging in Patients With Ischemic Stroke.

Beth Whittington, Craig Balmforth, Alessandro Giaj Levra, Laura Clark, Neil Craig, Audrey White, Krithika Loganath, Evangelos Tzolos, Allison Winarski, Rachael O Forsythe and 20 more

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Circulation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05636748 (The Origin and Role of Thromboembolism in the Pathogenesis of Ischaemic Stroke), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05636748 recruitingnot on this map

The Origin and Role of Thromboembolism in the Pathogenesis of Ischaemic Stroke

TypeobservationalSponsorUniversity of EdinburghRan2023 to 2026Enrolled120ConditionsStroke, PET, ThrombosisArms18F-GP1 PET/CT, Agitated Contrast Echocardiogram, MRI Head, ECG Monitoring
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Beth Whittington *British Heart Foundation Center of Research Excellence (B.W., C.B., A.G.L., L.C., N.C., A. White, K.L., E.T., A. Winarski, R.O.F., M.M., T.R., P.H.K., S.N., M.G.M., S.V., M.B., E.J.R.v.B., M.R.D., M.C.W., D.E.N.), University of Edinburgh, Edinburgh, United Kingdom.ORCID 0000-0003-2833-5980
Craig Balmforth *British Heart Foundation Center of Research Excellence (B.W., C.B., A.G.L., L.C., N.C., A. White, K.L., E.T., A. Winarski, R.O.F., M.M., T.R., P.H.K., S.N., M.G.M., S.V., M.B., E.J.R.v.B., M.R.D., M.C.W., D.E.N.), University of Edinburgh, Edinburgh, United Kingdom.ORCID 0009-0005-1991-0017
Alessandro Giaj LevraBritish Heart Foundation Center of Research Excellence (B.W., C.B., A.G.L., L.C., N.C., A. White, K.L., E.T., A. Winarski, R.O.F., M.M., T.R., P.H.K., S.N., M.G.M., S.V., M.B., E.J.R.v.B., M.R.D., M.C.W., D.E.N.), University of Edinburgh, Edinburgh, United Kingdom.ORCID 0000-0001-7779-5276
Laura ClarkBritish Heart Foundation Center of Research Excellence (B.W., C.B., A.G.L., L.C., N.C., A. White, K.L., E.T., A. Winarski, R.O.F., M.M., T.R., P.H.K., S.N., M.G.M., S.V., M.B., E.J.R.v.B., M.R.D., M.C.W., D.E.N.), University of Edinburgh, Edinburgh, United Kingdom.
Neil CraigBritish Heart Foundation Center of Research Excellence (B.W., C.B., A.G.L., L.C., N.C., A. White, K.L., E.T., A. Winarski, R.O.F., M.M., T.R., P.H.K., S.N., M.G.M., S.V., M.B., E.J.R.v.B., M.R.D., M.C.W., D.E.N.), University of Edinburgh, Edinburgh, United Kingdom.ORCID 0000-0002-2882-578X
Audrey WhiteBritish Heart Foundation Center of Research Excellence (B.W., C.B., A.G.L., L.C., N.C., A. White, K.L., E.T., A. Winarski, R.O.F., M.M., T.R., P.H.K., S.N., M.G.M., S.V., M.B., E.J.R.v.B., M.R.D., M.C.W., D.E.N.), University of Edinburgh, Edinburgh, United Kingdom.
Krithika LoganathBritish Heart Foundation Center of Research Excellence (B.W., C.B., A.G.L., L.C., N.C., A. White, K.L., E.T., A. Winarski, R.O.F., M.M., T.R., P.H.K., S.N., M.G.M., S.V., M.B., E.J.R.v.B., M.R.D., M.C.W., D.E.N.), University of Edinburgh, Edinburgh, United Kingdom.
Evangelos TzolosBritish Heart Foundation Center of Research Excellence (B.W., C.B., A.G.L., L.C., N.C., A. White, K.L., E.T., A. Winarski, R.O.F., M.M., T.R., P.H.K., S.N., M.G.M., S.V., M.B., E.J.R.v.B., M.R.D., M.C.W., D.E.N.), University of Edinburgh, Edinburgh, United Kingdom.ORCID 0000-0003-0038-043X
Allison WinarskiBritish Heart Foundation Center of Research Excellence (B.W., C.B., A.G.L., L.C., N.C., A. White, K.L., E.T., A. Winarski, R.O.F., M.M., T.R., P.H.K., S.N., M.G.M., S.V., M.B., E.J.R.v.B., M.R.D., M.C.W., D.E.N.), University of Edinburgh, Edinburgh, United Kingdom.ORCID 0000-0002-1135-4993
Rachael O ForsytheBritish Heart Foundation Center of Research Excellence (B.W., C.B., A.G.L., L.C., N.C., A. White, K.L., E.T., A. Winarski, R.O.F., M.M., T.R., P.H.K., S.N., M.G.M., S.V., M.B., E.J.R.v.B., M.R.D., M.C.W., D.E.N.), University of Edinburgh, Edinburgh, United Kingdom.
Michael McDermottBritish Heart Foundation Center of Research Excellence (B.W., C.B., A.G.L., L.C., N.C., A. White, K.L., E.T., A. Winarski, R.O.F., M.M., T.R., P.H.K., S.N., M.G.M., S.V., M.B., E.J.R.v.B., M.R.D., M.C.W., D.E.N.), University of Edinburgh, Edinburgh, United Kingdom.ORCID 0000-0002-5658-344X
Tariq RamtoolaBritish Heart Foundation Center of Research Excellence (B.W., C.B., A.G.L., L.C., N.C., A. White, K.L., E.T., A. Winarski, R.O.F., M.M., T.R., P.H.K., S.N., M.G.M., S.V., M.B., E.J.R.v.B., M.R.D., M.C.W., D.E.N.), University of Edinburgh, Edinburgh, United Kingdom.ORCID 0000-0002-4036-9043
Phyo H KhaingBritish Heart Foundation Center of Research Excellence (B.W., C.B., A.G.L., L.C., N.C., A. White, K.L., E.T., A. Winarski, R.O.F., M.M., T.R., P.H.K., S.N., M.G.M., S.V., M.B., E.J.R.v.B., M.R.D., M.C.W., D.E.N.), University of Edinburgh, Edinburgh, United Kingdom.
Sphamandla NtshangaseBritish Heart Foundation Center of Research Excellence (B.W., C.B., A.G.L., L.C., N.C., A. White, K.L., E.T., A. Winarski, R.O.F., M.M., T.R., P.H.K., S.N., M.G.M., S.V., M.B., E.J.R.v.B., M.R.D., M.C.W., D.E.N.), University of Edinburgh, Edinburgh, United Kingdom.
Mark G MacaskillBritish Heart Foundation Center of Research Excellence (B.W., C.B., A.G.L., L.C., N.C., A. White, K.L., E.T., A. Winarski, R.O.F., M.M., T.R., P.H.K., S.N., M.G.M., S.V., M.B., E.J.R.v.B., M.R.D., M.C.W., D.E.N.), University of Edinburgh, Edinburgh, United Kingdom.ORCID 0000-0001-5355-3109
Stefan VeizadesBritish Heart Foundation Center of Research Excellence (B.W., C.B., A.G.L., L.C., N.C., A. White, K.L., E.T., A. Winarski, R.O.F., M.M., T.R., P.H.K., S.N., M.G.M., S.V., M.B., E.J.R.v.B., M.R.D., M.C.W., D.E.N.), University of Edinburgh, Edinburgh, United Kingdom.ORCID 0000-0002-3829-3537
Mairi BrittanBritish Heart Foundation Center of Research Excellence (B.W., C.B., A.G.L., L.C., N.C., A. White, K.L., E.T., A. Winarski, R.O.F., M.M., T.R., P.H.K., S.N., M.G.M., S.V., M.B., E.J.R.v.B., M.R.D., M.C.W., D.E.N.), University of Edinburgh, Edinburgh, United Kingdom.ORCID 0000-0002-3830-200X
Tim ClarkEdinburgh Imaging, Queen's Medical Research Institute, Edinburgh, United Kingdom (T.C., M.R., C.L.).
Michelle RooneyEdinburgh Imaging, Queen's Medical Research Institute, Edinburgh, United Kingdom (T.C., M.R., C.L.).ORCID 0009-0007-1651-171X
Christophe LucatelliEdinburgh Imaging, Queen's Medical Research Institute, Edinburgh, United Kingdom (T.C., M.R., C.L.).ORCID 0000-0001-9866-7257
Piotr J SlomkaCedars-Sinai Medical Center, Los Angeles, CA (P.J.S.).ORCID 0000-0002-6110-938X
Norman KoglinLantheus Germany GmbH, Berlin, Germany (N.K., A.W.S., I.H.).ORCID 0000-0001-7583-8201
Andrew W StephensLantheus Germany GmbH, Berlin, Germany (N.K., A.W.S., I.H.).ORCID 0000-0001-5052-6586
Iris HardewigLantheus Germany GmbH, Berlin, Germany (N.K., A.W.S., I.H.).ORCID 0000-0001-9865-9302
Edwin J R van BeekBritish Heart Foundation Center of Research Excellence (B.W., C.B., A.G.L., L.C., N.C., A. White, K.L., E.T., A. Winarski, R.O.F., M.M., T.R., P.H.K., S.N., M.G.M., S.V., M.B., E.J.R.v.B., M.R.D., M.C.W., D.E.N.), University of Edinburgh, Edinburgh, United Kingdom.ORCID 0000-0002-2777-5071
Marc R DweckBritish Heart Foundation Center of Research Excellence (B.W., C.B., A.G.L., L.C., N.C., A. White, K.L., E.T., A. Winarski, R.O.F., M.M., T.R., P.H.K., S.N., M.G.M., S.V., M.B., E.J.R.v.B., M.R.D., M.C.W., D.E.N.), University of Edinburgh, Edinburgh, United Kingdom.ORCID 0000-0001-9847-5917
Joanna WardlawInstitute of Neuroscience and Cardiovascular Research (J.W., W.N.W.), University of Edinburgh, Edinburgh, United Kingdom.ORCID 0000-0002-9812-6642
Michelle C Williams *British Heart Foundation Center of Research Excellence (B.W., C.B., A.G.L., L.C., N.C., A. White, K.L., E.T., A. Winarski, R.O.F., M.M., T.R., P.H.K., S.N., M.G.M., S.V., M.B., E.J.R.v.B., M.R.D., M.C.W., D.E.N.), University of Edinburgh, Edinburgh, United Kingdom.ORCID 0000-0003-3556-2428
William N Whiteley *Institute of Neuroscience and Cardiovascular Research (J.W., W.N.W.), University of Edinburgh, Edinburgh, United Kingdom.ORCID 0000-0002-4816-8991
David E Newby *British Heart Foundation Center of Research Excellence (B.W., C.B., A.G.L., L.C., N.C., A. White, K.L., E.T., A. Winarski, R.O.F., M.M., T.R., P.H.K., S.N., M.G.M., S.V., M.B., E.J.R.v.B., M.R.D., M.C.W., D.E.N.), University of Edinburgh, Edinburgh, United Kingdom.ORCID 0000-0001-7971-4628

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDetermining the source of thromboembolism in patients with acute ischemic stroke remains challenging because current diagnostic approaches rely largely on circumstantial and inferential associations rather than direct identification of the cause of stroke. Fluorine-18 GP1 ([

methodsIn a single-center prospective observational cohort study, 100 patients presenting with acute ischemic stroke underwent hybrid [

resultsCardiovascular [

conclusionsNoninvasive thrombosis imaging is a novel technique that enables direct in vivo identification of thrombus formation and frequently reveals the source of thromboembolism in patients with acute ischemic stroke. This approach represents a shift from inference-based to mechanism-based stroke classification with potential implications for targeted prevention strategies and better patient outcomes. REGISTRATION: URL: https://www.clinicaltrials.gov; Unique Identifier: NCT05636748.

Indexed as

Brain IschemiaComputed Tomography AngiographyIschemic StrokePositron Emission Tomography Computed TomographyThrombosisAgedAged, 80 and overFemaleHumansMaleMiddle AgedProspective StudiesRadiopharmaceuticalsRadiopharmaceuticalsatherosclerosisplateletspositron emission tomographystrokethrombosis

Identifiers

PMID42677492
PMCPMC13668038

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.