ReviewChemical reviews2026
Protein Modifications for Cellular Protein Delivery.
Review in Chemical reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
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Authors and funding
5 authors.
Funding
Abstract
Intracellular delivery of functional proteins is emerging as a powerful strategy to interrogate and control cellular pathways with high spatial and temporal precision. Recent advances in chemical biology now enable the design of cell-permeable proteins through precise chemical and biochemical modification, bringing the field closer to achieving intracellularly targeted biologics as a "new class of drugs". By overcoming the limitations of genetic manipulation, researchers create solutions for basic research and medicine. In this review, we outline the key motivations that drive intracellular protein delivery. We highlight central mechanistic paradigms for protein entry, important parameters influencing protein delivery, and summarize analytical tools to assess successful delivery. We outline different chemical and biochemical conceptional approaches that resulted in breakthrough studies to achieve functional protein transport. Finally, we discuss ongoing efforts, highlighting the challenges for future research on protein delivery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.