Evidence map›Paper›PMID 42677384›Full record

ReviewCell biochemistry and function2026

Revising NHE-1: From Cardiac Homeostasis to Heart Failure and Future Drug Development.

Vasileios Bouratzis, Nikoleta Douskou, Nikolaos P Tzavellas, Yannis V Simos, Petros Bozidis, Konstantinos I Tsamis, Georgios S Markopoulos, Dimitrios Peschos, Lampros Lakkas

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cell biochemistry and function, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Vasileios BouratzisSecond Department of Cardiology, University of Ioannina Medical School, Ioannina, Greece.ORCID https://orcid.org/0000-0001-5761-5311
Nikoleta DouskouSecond Department of Cardiology, University of Ioannina Medical School, Ioannina, Greece.
Nikolaos P TzavellasDepartment of Physiology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece.ORCID https://orcid.org/0009-0000-4182-7627
Yannis V SimosDepartment of Physiology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece.ORCID https://orcid.org/0000-0003-1764-8906
Petros BozidisMicrobiology Department, School of Health Science, Faculty of Medicine, University of Ioannina, Ioannina, Greece.ORCID https://orcid.org/0000-0003-4058-1164
Konstantinos I TsamisDepartment of Physiology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece.ORCID https://orcid.org/0000-0002-7032-1630
Georgios S MarkopoulosDepartment of Physiology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece.
Dimitrios PeschosDepartment of Physiology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece.
Lampros LakkasDepartment of Physiology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece.ORCID https://orcid.org/0000-0001-9401-3125

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

NHE-1 is a Na

Indexed as

Drug DevelopmentHeart FailureHomeostasisSodium-Hydrogen Exchanger 1AnimalsHumansMyocytes, CardiacSLC9A1 protein, humanSodium-Hydrogen Exchanger 1

Identifiers

PMID42677384
PMCPMC13531398

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.