ArticleACS catalysis2026
Iridium-Catalyzed ortho-Directed C-H Borylation of Nitroarenes.
Article in ACS catalysis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
ortho-Boryl nitroarenes have vast applications as building blocks in organic synthesis. Traditional methods of synthesizing these compounds require an ortho-halo nitroarene starting material and often stringent conditions. Directed ortho-borylation of nitroarenes presents an alternative, attractive strategy that could utilize simple nitroarenes as a feedstock. Herein, we report a cationic iridium pre-catalyst and triarylarsine ligands as competent catalyst systems that selectively borylate nitroarenes at the ortho position. This nitro-directed C-H borylation tolerates a wide range of substrates, providing access to diverse ortho-boryl nitroarenes in high yield that can either be isolated directly or reacted without purification to provide functionalized nitroarenes. Finally, we also demonstrate that ortho-boryl nitroarenes can serve as a platform for the synthesis of diverse aromatic products, including in the preparation of 1,2-difunctionalized arenes.
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