Evidence map›Paper›PMID 42677266›Full record

ArticleTurkish journal of medical sciences2026

RNA sequencing detects more challenging cases of somatic hypermutation in the

Fatma Arikan, Pınar Ata, Şenol Demir, Meral Uluköylü Mengüç, Fahir Özkalemkaş, Bedrettin Orhan, Özgür Mehtap, Arda Bayar, Asu Fergün Yilmaz, Ayşe Tülin Tuğlular and 2 more

Abstract read
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In one paragraph

Article in Turkish journal of medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Fatma ArikanDivision of Hematology, Department of Internal Medicine, Faculty of Medicine, Marmara University Pendik Training and Research Hospital, İstanbul, Turkiye.ORCID https://orcid.org/0000-0002-4059-1250
Pınar AtaDivision of Genetics and Molecular Research, Department of Medical Genetics, Faculty of Medicine, Marmara University Pendik Training and Research Hospital, İstanbul, Turkiye.ORCID https://orcid.org/0000-0002-2399-2888
Şenol DemirDivision of Genetics and Molecular Research, Department of Medical Genetics, Faculty of Medicine, Marmara University Pendik Training and Research Hospital, İstanbul, Turkiye.ORCID https://orcid.org/0000-0002-8374-0359
Meral Uluköylü MengüçDivision of Hematology, Department of Internal Medicine, Faculty of Medicine, Marmara University Pendik Training and Research Hospital, İstanbul, Turkiye.ORCID https://orcid.org/0000-0002-4303-9488
Fahir ÖzkalemkaşDivision of Hematology, Department of Internal Medicine, Faculty of Medicine, Uludağ University, Bursa, Turkiye.ORCID https://orcid.org/0000-0001-9710-134X
Bedrettin OrhanDivision of Hematology, Department of Internal Medicine, Faculty of Medicine, Uludağ University, Bursa, Turkiye.ORCID https://orcid.org/0000-0003-3970-2344
Özgür MehtapDivision of Hematology, Department of Internal Medicine, Faculty of Medicine, Kocaeli University, Kocaeli, Turkiye.ORCID https://orcid.org/0000-0002-5603-1178
Arda BayarDivision of Hematology, Department of Internal Medicine, Faculty of Medicine, Marmara University Pendik Training and Research Hospital, İstanbul, Turkiye.ORCID https://orcid.org/0000-0002-4586-3809
Asu Fergün YilmazDivision of Hematology, Department of Internal Medicine, Faculty of Medicine, Marmara University Pendik Training and Research Hospital, İstanbul, Turkiye.ORCID https://orcid.org/0000-0001-5118-6894
Ayşe Tülin TuğlularDivision of Hematology, Department of Internal Medicine, Faculty of Medicine, Marmara University Pendik Training and Research Hospital, İstanbul, Turkiye.ORCID https://orcid.org/0000-0003-3232-7545
Işık AtagündüzDivision of Hematology, Department of Internal Medicine, Faculty of Medicine, Marmara University Pendik Training and Research Hospital, İstanbul, Turkiye.ORCID https://orcid.org/0000-0002-7876-6896
Tayfur ToptaşDivision of Hematology, Department of Internal Medicine, Faculty of Medicine, Marmara University Pendik Training and Research Hospital, İstanbul, Turkiye.ORCID https://orcid.org/0000-0002-2690-8581

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background/aim: Chronic lymphocytic leukemia (CLL) exhibits marked biological heterogeneity, and immunoglobulin heavy chain variable ( Materials and methods: Eighty-seven adults diagnosed with CLL between 2020 and 2022 at three centers were included. Total RNA from peripheral blood underwent anchored multiplex polymerase chain reaction with the Immunoverse BCR-IGH IGKL v1.0 kit (Integrated DNA Technologies) and was sequenced on the MiSeq platform (Illumina). Results: Median age at diagnosis was 60 years and 64% of patients were male. RNA-seq identified double Conclusion: RNA-seq provided detailed insight into

Indexed as

Immunoglobulin Heavy ChainsImmunoglobulin Variable RegionLeukemia, Lymphocytic, Chronic, B-CellSequence Analysis, RNASomatic Hypermutation, ImmunoglobulinAdultAgedFemaleHumansMaleMiddle AgedMutationPrognosisRetrospective StudiesImmunoglobulin Heavy ChainsImmunoglobulin Variable RegionChronic lymphocytic leukemiaRNA sequencingsomatic hypermutation

Identifiers

PMID42677266
PMCPMC13528727

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.