ArticleTurkish journal of medical sciences2026
Histomorphological changes in human septal cartilage stored in different preservation solutions.
Article in Turkish journal of medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background/aim: To assess the histopathological effects of three preservation solutions (70% ethanol, povidone-iodine, and ciprofloxacin) on human septal cartilage obtained during septoplasty and to compare their preservation characteristics for potential future graft applications. Optimal preservation of septal cartilage is clinically important because well-preserved grafts may reduce the need for secondary cartilage harvesting and the associated donor-site morbidity while facilitating reconstructive procedures during revision surgery. Materials and methods: A total of 90 septal cartilage specimens obtained from 30 patients undergoing septoplasty were allocated to three preservation groups and stored in the designated preservation solutions at +4 °C. Samples were examined histologically on days 0, 15, and 30. The evaluated parameters included chondrocyte count/cellularity, the percentage of empty lacunae, chondrocyte morphology, erosion score, inflammation, and necrosis. Evaluations were blinded. Results: Progressive time-dependent histomorphological deterioration was observed in all preservation groups. From baseline to day 30, the ciprofloxacin group showed a greater reduction in chondrocyte count and a greater increase in the percentage of empty lacunae than the povidone-iodine group (adjusted p = 0.043 and p = 0.029, respectively). Although ethanol showed relatively favorable morphological findings at day 15, substantial deterioration was observed by day 30. Chondrocyte morphology and erosion scores also deteriorated over time. Inflammation and necrosis remained minimal across all groups. Conclusion: All tested preservation solutions were associated with progressive, time-dependent histomorphological deterioration of septal cartilage. No single preservation solution demonstrated consistently superior preservation across all evaluated histopathological parameters. Further biomechanical and biochemical studies are required to establish optimal cartilage preservation protocols.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.