Evidence map›Paper›PMID 42677223›Full record

ArticleChem2026

Skeletal editing by iron-catalyzed carbene insertion of trichloromethanes.

Bethany M DeMuynck, Ethan E Hyland, Hojin Kim, Victoria L Menches, Anna M M Vernier, Zhang Wang, David E Olson, Mark D Levin, David A Nagib

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chem, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Deconstruction of lysergic acid diethylamide.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Bethany M DeMuynckDepartment of Chemistry and Biochemistry, the Ohio State University, Columbus, OH 43210, USA.
Ethan E HylandDepartment of Chemistry, University of Chicago, Chicago, IL 60637, USA.
Hojin KimDepartment of Chemistry and Biochemistry, the Ohio State University, Columbus, OH 43210, USA.
Victoria L MenchesDepartment of Chemistry and Biochemistry, the Ohio State University, Columbus, OH 43210, USA.
Anna M M VernierInstitute for Psychedelics and Neurotherapeutics, University of California, Davis, Davis, CA 95616, USA.
Zhang WangInstitute for Psychedelics and Neurotherapeutics, University of California, Davis, Davis, CA 95616, USA.
David E OlsonInstitute for Psychedelics and Neurotherapeutics, University of California, Davis, Davis, CA 95616, USA.
Mark D LevinDepartment of Chemistry, University of Chicago, Chicago, IL 60637, USA.
David A NagibDepartment of Chemistry and Biochemistry, the Ohio State University, Columbus, OH 43210, USA.

Funding

Radical Chaperones to Harness Remote, Selective C-H Functionalization MechanismsR35GM119812 · NIGMS · OHIO STATE UNIVERSITY · PI NAGIB, DAVID A · 2016 to 2025
$4.0M
High-throughput Identification of Non-hallucinogenic Psychoplastogens for Treating AddictionR01DA056365 · NIDA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI David E Olson · 2022 to 2026
$2.7M
Construction of Heteroarenes Through Single Atom I-RenewalR35GM142768 · NIGMS · UNIVERSITY OF CHICAGO · PI Mark Daniel Levin · 2021 to 2026
$2.6M
Supplement: Chemical and Molecular Tools for Modulating GPCR FunctionR35GM148182 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI David E Olson · 2023 to 2026
$1.5M
NIDA NIH HHS R01 DA056365NIGMS NIH HHS R35 GM119812NIGMS NIH HHS R35 GM142768NIGMS NIH HHS R35 GM148182
6 · The paper itself

Abstract

Direct interchange between five- and six-membered nitrogen heterocycles by skeletal editing is valuable in drug discovery. Specifically, inserting a carbon atom into oxidatively prone indole affords metabolically stable quinoline. However, tailored reagents for this transformation are limited by safety, availability, and generality. Here, we introduce a C-insertion method that employs stable, commercially abundant trichloromethanes (as chlorocarbene precursors) and simple iron catalysts (FeCl

Identifiers

PMID42677223
PMCPMC13528700

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.