Evidence map›Paper›PMID 42677151›Full record

ArticleGenetic and Evolutionary Computation Conference : [proceedings]. Genetic and Evolutionary Computation Conference2025

Rule-based Machine Learning: Separating Rule and Rule-Set Pareto-Optimization for Interpretable Noise-Agnostic Modeling.

Gabriel Lipschutz-Villa, Harsh Bandhey, Ruonan Yin, Malek Kamoun, Ryan J Urbanowicz

Abstract read
In one paragraph

Article in Genetic and Evolutionary Computation Conference : [proceedings]. Genetic and Evolutionary Computation Conference, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Phase-Alternation and Tree-Initialization to Facilitate Interpretable Rule-based Machine Learning.Genetic and Evolutionary Computation Conference : [proceedings]. Genetic and Evolutionary Computation Conference · 2026
    Article
  2. Audience-Customized Translation of Rule-Based Evidence with Large Language Models Across Multiplexer Benchmarks.Genetic and Evolutionary Computation Conference : [proceedings]. Genetic and Evolutionary Computation Conference · 2026
    Article
  3. Survival-LCS: Rule-Based Survival Analysis without Proportional Hazard Assumptions.ACM transactions on evolutionary learning and optimization · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Gabriel Lipschutz-VillaUniversity of Pennsylvania, Philadelphia, PA, USA.
Harsh BandheyCedars-Sinai Medical Center, Los Angeles, CA, USA.
Ruonan YinIndependent Consultant, Los Angeles, CA, USA.
Malek KamounUniversity of Pennsylvania, Philadelphia, PA, USA.
Ryan J UrbanowiczCedars-Sinai Medical Center, Los Angeles, CA, USA.

Funding

Technology Identification and Training CoreP30AG073105 · NIA · UNIVERSITY OF PENNSYLVANIA · PI DEMIRIS, GEORGE, KARLAWISH, JASON H · 2021 to 2025
$21.2M
Artificial Intelligence Strategies for Alzheimer's Disease ResearchU01AG066833 · NIA · CEDARS-SINAI MEDICAL CENTER · PI MOORE, JASON H., RITCHIE, MARYLYN D · 2022 to 2025
$6.7M
HLA Immunogenetics and kidney allograft outcomesR01AI173095 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Malek Kamoun · 2023 to 2026
$3.1M
NIAID NIH HHS R01 AI173095NIA NIH HHS P30 AG073105NIA NIH HHS U01 AG066833
6 · The paper itself

Abstract

Rule-based machine learning (RBML) algorithms, e.g. learning classifier systems (LCSs), can capture complex relationships while yielding more interpretable models than most other machine learning algorithms. Traditional LCSs rely on a single fitness function for both rule and/or rule-set optimization. However, ideal rule vs. rule-set discovery often requires distinct and multiple objectives. Recently, hybrid-LCSs were proposed that explicitly separated the task of rule vs. rule-set discovery but relied on distinct single-objective or weighted multi-objective fitness functions. This study introduces a newly developed Heuristic Evolutionary Rule Optimization System (HEROS) that combines previous LCS innovations aimed at tackling noisy, larger-scale, classification tasks, while adopting separation of rule vs. rule-set evolution. Uniquely, HEROS employs a custom Pareto-front-based multi-objective fitness function (for rule discovery) and NSGA-II-style multi-objective optimization (for rule-set discovery) to solve both clean and noisy-signal classification problems agnostically. Rule discovery is driven by rule-accuracy and instance coverage objectives, while rule-set discovery is driven by prediction accuracy and rule-set size objectives. Using diverse simulated benchmark datasets, i.e. noisy (GAMETES) and clean (MUX), we demonstrate proof-of-principle that HEROS can directly discover accurate, highly-compact, interpretable, and ideal solutions when compared to the established 'ExSTraCS' RBML algorithm, without objective weightings or adjusting hyperparameters.

Indexed as

InterpretabilityLearning Classifier SystemsMulti-objective OptimizationRule-based Machine LearningSupervised Learning

Identifiers

PMID42677151
PMCPMC13528404

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.